Registration Dossier
Registration Dossier
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EC number: 223-296-5 | CAS number: 3811-73-2
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Hydrolysis as a function of pH at 25degrees C. Federal Register Vol. 50, No. 188 (1985) Rules and Regulations p 39252
- GLP compliance:
- yes
Test material
- Reference substance name:
- Pyridine-2-thiol 1-oxide, sodium salt
- EC Number:
- 223-296-5
- EC Name:
- Pyridine-2-thiol 1-oxide, sodium salt
- Cas Number:
- 3811-73-2
- Molecular formula:
- C5H5NOS.Na
- IUPAC Name:
- sodium (1-oxo-1λ⁵-pyridin-2-yl)sulfanide
- Details on test material:
- - Analytical purity: 40%
- Lot/batch No.: 64/95
Constituent 1
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals: 0, 7, 14, 21, 28 days
- Buffers:
- pH3 buffer: 500ml 0.1M KH-phthalate + 222ml 0.1M HCl adjusted to 1L with deionised water
pH7 buffer: 500ml 0.1M KH2-phosphate + 290ml 0.1M NaOH adjusted to 1L with deionised water
pH11 buffer: 500ml 0.05M Na-bicarbonate + 226ml 0.1M NaOH adjusted to 1L with deionised water
Duration of test
- Duration:
- 28 d
- Initial conc. measured:
- 140 mg/L
- Number of replicates:
- 3 per pH
Results and discussion
- Transformation products:
- no
Total recovery of test substance (in %)open allclose all
- % Recovery:
- 86
- pH:
- 3
- Temp.:
- 25 °C
- Duration:
- 7 d
- % Recovery:
- 86
- pH:
- 3
- Temp.:
- 25 °C
- Duration:
- 14 d
- % Recovery:
- 100
- pH:
- 3
- Temp.:
- 25 °C
- Duration:
- 21 d
- % Recovery:
- 93
- pH:
- 3
- Temp.:
- 25 °C
- Duration:
- 28 d
- % Recovery:
- 100
- pH:
- 7
- Temp.:
- 25 °C
- Duration:
- 7 d
- % Recovery:
- 95
- pH:
- 7
- Temp.:
- 25 °C
- Duration:
- 14 d
- % Recovery:
- 100
- pH:
- 7
- Temp.:
- 25 °C
- Duration:
- 21 d
- % Recovery:
- 100
- pH:
- 7
- Temp.:
- 25 °C
- Duration:
- 28 d
- % Recovery:
- 112
- pH:
- 11
- Temp.:
- 25 °C
- Duration:
- 7 d
- % Recovery:
- 91
- pH:
- 11
- Temp.:
- 25 °C
- Duration:
- 14 d
Dissipation DT50 of parent compound
- pH:
- 3
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Details on results:
- Hydrolysis rate constant (Kh) is zero for each of the pHs
Any other information on results incl. tables
pH |
Sampling times (days) Percent prepared concentration |
|||||||
7 |
14 |
21 |
28 |
|
|
|
|
|
3 |
86 |
86 |
100 |
93 |
|
|
|
|
7 |
100 |
95 |
100 |
100 |
|
|
|
|
11 |
112 |
91 |
98 |
100 |
|
|
|
|
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- No DT50 for hydrolysis could be determined after 28 days in pH 3, 7, and 11 buffer. The information contained within this robust summary document comes from studies which are in the ownership of Arch Chemicals Inc. and which are protected in several regions globally. This information may not be used for any purpose other than in support of the Chemical safety Report submitted by Arch Chemicals Inc. under Regulation EC 1907/2006.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
