Registration Dossier
Registration Dossier
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EC number: 224-030-0 | CAS number: 4170-30-3
Endpoint summary
Administrative data
Description of key information
A few pre-guideline studies in animals were available for this evaluation demonstrating that the test material is highly irritating to the skin and eye and confirmed with some basic evaluations in humans.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Experimental studies in animals and humans showed that crotonaldehyde causes skin irritation and serious damage to the eyes. No studies were identified regarding respiratory irritation. However, acute inhalation toxicity studies suggested that crotonaldehyde causes irritation to the nose and respiratory tract in rats (Eastman Kodak, 1961).
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: highly irritating
Effects on respiratory irritation: irritating
Justification for classification or non-classification
According to the criteria in regulation (EC) No. 1272/2008, as well as the requirements of Annex VI thereof, the substance is classified as skin irritant Catergory 2 and eye damage Category 1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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