Registration Dossier
Registration Dossier
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EC number: 224-030-0 | CAS number: 4170-30-3
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.65 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 1.1 mg/L
Additional information
A total of six studies are available assessing the acute effects of crotonaldehyde to fish. Five studies were conducted with freshwater fish, and one used a marine species as test organism. In all of these studies, a similar sensitivity of crotonaldehyde to the different fish species could be shown. The most sensitive endpoint was derived from a study conducted with Rainbow trout under flow-through conditions, reporting a 96 -hour LC50 of 0.65 mg/L. This endpoint is based on mean measured test concentrations. In another flow-through study conducted with Fathead minnow, a 96 -hour LC50 of 0.84 mg/L was derived, also based on mean measured values. A study conducted with Bluegill sunfish under static conditions reported a 96 -hour LC50 of 3 mg/L, based on nominal values. All studies are described in sufficient detail and can be regarded as reliable.
Two 48 -hour studies with Golden orfe are available, reporting LC0 values of 1 and 2 mg/L, respectively, both values based on nominal concentrations. For both tests, there is only little information available about the study design and the test conditions, and the description of the studies is not very detailed. They are therefore regarded as supporting information.
One study was conducted with the saltwater fish Tidewater silverside. In this study, a 96 -hour LC50 of 1.1 mg/L, based on nominal values is reported.
A study conducted under flow-through conditions represents the worst case of exposure to the test item over time. Under these conditions, the exposure to degradation products is not very likely. Furthermore, analytical measurement of the test concentration during the whole test period give a better impression about the decrease of the test item over time, as a static test design does. The study using Rainbow trout was conducted under the above described conditions. As in this study, the lowest toxicity value of all studies was derived, it was selected as the key study.
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