Registration Dossier
Registration Dossier
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EC number: 224-030-0 | CAS number: 4170-30-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Acceptable (pre-GLP; pre-guidelines), study containing basic data which suggests that basic scientific principles have been met. This is sufficient to judge the results reliable as a contribution to the understanding of the toxicity of this substance.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 944
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Administering doses differing by a multiple of ten to 6 guinea pigs by retaining the sample in absorbent cotton over the clipped abdomen of the animal for four days and observing for 10 additional days or until death.
- GLP compliance:
- no
- Test type:
- other:
- Limit test:
- no
Test material
- Reference substance name:
- Crotonaldehyde
- EC Number:
- 224-030-0
- EC Name:
- Crotonaldehyde
- Cas Number:
- 4170-30-3
- Molecular formula:
- C4H6O
- IUPAC Name:
- but-2-enal
- Details on test material:
- none
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- clipped abdomen
- Duration of exposure:
- 4 days
- Doses:
- no data
- No. of animals per sex per dose:
- 6
- Control animals:
- not required
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- ca. 26 mg/kg bw
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Interpretation of results:
- toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: US CPSC / US OSHA
- Conclusions:
- no data
- Executive summary:
In a skin penetration toxicology study 0.01 ml of crotonaldehdyed was applied to the clipped belly skin area of albino rabbits. Animals were observed for 24 hours and signs such as necrosis, edema, erythema or congestion of capillaries were recorded. In a skin penetration toxicology study in guinea pigs in which key basic details were reports, an application of the substance over the clipped abdomen for four days and observed for 10 additional days or until death resulted in an LD50 of c.a. 26 mg/kg body weight.
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