Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-854-9 | CAS number: 88-73-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- : no pathology performed, lack of details on test substance
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-chloro-2-nitrobenzene
- EC Number:
- 201-854-9
- EC Name:
- 1-chloro-2-nitrobenzene
- Cas Number:
- 88-73-3
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-2-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 2-Chlor-1-nitrobenzol
- Physical state: solid
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- polyethylene glycol
- Details on dermal exposure:
- TEST SITE
- Area of exposure: shaved back
- Type of wrap if used: covered by alu and plaster
REMOVAL OF TEST SUBSTANCE
- Washing (if done): rinsed with water and soap
- Time after start of exposure: 24 hours - Duration of exposure:
- 24 hours
- Doses:
- male rats: 250, 350, 500, 750, 1000, 1500 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 655 mg/kg bw
- Mortality:
- See details below
Any other information on results incl. tables
dosis conc. result signs of intoxication time of death
mg/kg % m /s /n start end
250 25 1/10/10 18 h 14 d 4 d
350 25 1/10/10 18 h 7 d 18 h
500 50 3/10/10 18 h 9 d 1-3 d
750 50 7/10/10 24 h 13 d 1-3 d
1000 50 7/10/10 18 h 4 d 18 h - 3 d
1500 75 9/10/10 18 h 14 d 18 h - 4 d
m: number of rats which died;
n: number of animals put in test
s: number of animals with signs of intoxication:
reduced general condition, difficulties in breathing,
cyanotic appearance, some animals showed lacrimation
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
