Registration Dossier
Registration Dossier
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EC number: 201-854-9 | CAS number: 88-73-3
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Adopted according to OECD SIDS, peer reviewed data
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- IRDC (International Research and Developmental Corporation): Modified teratology study in rats with o-Nitrochlorobenzene, Report no. ML-82-090A, october 1984 (at the request of Monsanto Company), EPA-OTS0522332
- Bibliographic source:
- (as cited in OECD SIDS)
- Reference Type:
- secondary source
- Title:
- 1-Chloro-2-nitrobenzene CAS: 88-73-3, SIDS Initial Assessment Report
- Author:
- OECD
- Year:
- 2 001
- Bibliographic source:
- UNEP publications
Materials and methods
- Principles of method if other than guideline:
- 25 females/group, only one dose
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-chloro-2-nitrobenzene
- EC Number:
- 201-854-9
- EC Name:
- 1-chloro-2-nitrobenzene
- Cas Number:
- 88-73-3
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-2-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 1-chloro-2-nitrobenzene
- Analytical purity: commercial
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- d6-d15
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 100 mg/kg bw in corn oil
Basis:
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Sex: female
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Dose descriptor:
- other: NOAEL developmental toxicity
- Effect level:
- ca. 100 mg/kg bw/day
Results (fetuses)
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
d6-10: slight maternal body weight loss accompanied by
reduction in food consumption for d6-16, maternal
reproductive parameters were not affected, fetal body weight
comparable to the respective controls; no teratogenic
effects were observed
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
