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EC number: 230-386-8 | CAS number: 7085-19-0
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 06 June 1988 to 18 June 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- gas saturation method
- Key result
- Temp.:
- ca. 22.5 °C
- Vapour pressure:
- ca. 0.001 mm Hg
- Conclusions:
- Under the conditions of this study the average vapour pressure for the test material is 8.98 x 10^-4 mm Hg.
- Executive summary:
The vapour pressure of the test material was determined using the gas saturation method and was assessed according to OECD 104 and in compliance with GLP.
A nitrogen stream saturated with the test material flowed through cold trapping apparatus. The test material trapped was analysed using HPLC and the vapour pressure calculated according to the ideal gas equation.
Under the conditions of this study the average vapour pressure for the test material is 8.98 x 10^-4 mm Hg.
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 July 2000 to 31 July 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: JMAFF Guidelines
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: vapour pressure balance
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 0.002 Pa
- Conclusions:
- Under the conditions of this study, the vapour pressure of the test material was found to be 0.0016 Pa at 25 °C.
- Executive summary:
The vapour pressure of the test material was determined using a vapour pressure balance and was assessed according to OECD Test Guideline 104 and E.U. method A.4 and in compliance with GLP.
Under the conditions of this study, the vapour pressure of the test material was found to be 0.0016 Pa at 25 °C.
Referenceopen allclose all
Recovery data for the extraction and trapping efficiency of the cold-trap tubing (which also indicated the stability of the test material under operating conditions) showed that no correction factor had to be applied to the data in either case.
A mean vapour pressure (three replicates) of 8.98 x 10^-04 mmHg was obtained for the test material.
Example of Standard Curve Data for Vapour Pressure Determination of the Test Material
Concentration (μg/mL) |
Peak Height (mm) |
Average Peak Height (mm) |
160 |
150, 144 |
147 |
80 |
73, 73 |
73 |
40 |
33, 31 |
32 |
16 |
11, 12 |
11.5 |
Correlation coefficient (r): 0.9998
Extraction Efficiency of the Test Material from the Trapping Agent (Pyrex Cold-Trap Tubing)
Replicate |
Amount of Test Material Spiked (μg) |
Amount of Test Material Extracted (μg) |
Recovery (%) |
A |
99.9 |
92.5 |
92 |
B |
99.9 |
112 |
112 |
C |
99.9 |
98.5 |
98 |
Extraction solvent: Acetonitrile
Stability of the Test Material and Trapping Efficiency of the Trapping Agent (Pyrex Cold-Trap Tubing)
Replicate |
Amount of Test Material Spiked (μg) |
Amount of Test Material Extracted (μg) |
Nitrogen Flow Rate (mL/Min) |
Temperature (°C) |
Time Exposed to Flow (Hours) |
Recovery (%) |
A |
99.9 |
98.4 |
5.2 |
21.3 |
72.75 |
98 |
B |
99.9 |
106 |
6.2 |
21.3 |
72.75 |
106 |
C |
99.9 |
102 |
9.5 |
21.3 |
72.75 |
102 |
Extraction solvent: Acetonitrile
Vapour Pressure of the Test Material
Replicate |
Nitrogen Flow Rate (mL/Min) |
Temperature (°C) |
Time Exposed to Flow (Hours) |
Vapour Pressure (mm Hg) |
A |
4.5 |
22.5 |
73.5 |
8.84 x 10^-04 |
B |
6.0 |
22.5 |
73.5 |
8.71 x 10^-04 |
C |
8.4 |
22.5 |
73.5 |
9.38 x 10^-04 |
Extraction solvent: Acetonitrile
Average: 8.98x 10^-04 mmHg
Standard deviation(SD): 3.55x 10^-05
Relative standard deviation ((SD / average) x 100): 4 %
The data from the first runs on each sample (runs 1 and 5) were not reported since it was considered that the sample was degassing during the tests. Runs 3 and 4 were not reported since the orifice of the apparatus became blocked during testing.
Summary of Results
|
Run 2 |
Run 6 |
Correlation |
-0.9564 |
-0.9978 |
Slope |
-2 944 |
-4 624 |
Intercept |
7.200 |
12.57 |
Log Vp at 25 °C |
-2.68 |
-2.94 |
Vp (Pa) at 25 °C |
0.00211 |
0.00116 |
The mean vapour pressure at 25 °C was 0.00164 Pa.
Determination of the Vapour Pressure of The Test Material (Run 2)
Temperature (°C) |
Mass Difference (µg) |
Condensation Rate (µg/s) |
Vapour Pressure (Pa) |
α |
Corrected Vapour Pressure |
1/Temperature (1/K) |
Log |
||
From |
From Condensation |
From |
From Condensation |
||||||
33.5 |
2.43 |
0.024 |
0.00401 |
0.00110 |
0.241 |
0.00456 |
0.00456 |
0.00326 |
-2.34 |
35.0 |
2.40 |
0.043 |
0.00395 |
0.00198 |
0.400 |
0.00494 |
0.00494 |
0.00325 |
-2.31 |
38.0 |
2.66 |
0.035 |
0.00439 |
0.00163 |
0.313 |
0.00521 |
0.00521 |
0.00321 |
-2.28 |
38.2 |
2.70 |
0.026 |
0.00445 |
0.00122 |
0.241 |
0.00506 |
0.00506 |
0.00321 |
-2.30 |
40.2 |
2.89 |
0.025 |
0.00477 |
0.00118 |
0.220 |
0.00535 |
0.00535 |
0.00319 |
-2.27 |
44.5 |
4.45 |
0.032 |
0.00734 |
0.00149 |
0.185 |
0.00808 |
0.00808 |
0.00315 |
-2.09 |
47.0 |
5.40 |
0.021 |
0.00891 |
0.00099 |
0.105 |
0.00940 |
0.00940 |
0.00312 |
-2.03 |
51.2 |
9.66 |
- |
0.01593 |
- |
- |
0.01593 |
- |
0.00308 |
-1.80 |
Determination of the Vapour Pressure of The Test Material (Run 6)
Temperature (°C) |
Mass Difference (µg) |
Condensation Rate (µg/s) |
Vapour Pressure (Pa) |
α |
Corrected Vapour Pressure (Pa) |
1/Temperature (1/K) |
Log |
||
From |
From Condensation |
From |
From Condensation |
||||||
29.0 |
1.18 |
- |
0.00194 |
- |
- |
0.00194 |
- |
0.00331 |
-2.71 |
31.0 |
1.41 |
- |
0.00232 |
- |
- |
0.00232 |
- |
0.00329 |
-2.63 |
34.5 |
2.09 |
- |
0.00345 |
- |
- |
0.00345 |
- |
0.00325 |
-2.46 |
37.0 |
2.66 |
- |
0.00439 |
- |
- |
0.00439 |
- |
0.00322 |
-2.36 |
38.5 |
3.27 |
- |
0.00539 |
- |
- |
0.00539 |
- |
0.00321 |
-2.27 |
39.0 |
3.61 |
- |
0.00596 |
- |
- |
0.00596 |
- |
0.00320 |
-2.22 |
41.5 |
4.49 |
- |
0.00740 |
- |
- |
0.00740 |
- |
0.00318 |
-2.13 |
42.5 |
5.36 |
- |
0.00884 |
- |
- |
0.00884 |
- |
0.00317 |
-2.05 |
Description of key information
Key Study: Comb (2000)
Under the conditions of this study, the vapour pressure of the test material was found to be 0.0016 Pa at 25 °C.
Supporting Study: Hoffman (1988)
Under the conditions of this study the average vapour pressure for the test material is 8.98 x 10^-4 mm Hg.
Key value for chemical safety assessment
- Vapour pressure:
- 0.002 Pa
- at the temperature of:
- 25 °C
Additional information
Key Study: Comb (2000)
The vapour pressure of the test material was determined using a vapour
pressure balance and was assessed according to OECD Test Guideline 104
and E.U. method A.4 and in compliance with GLP. The study was awarded a
reliability score of 1 in accordance with the criteria set forth by
Klimisch et al. (1997).
Under the conditions of this study, the vapour pressure of the test
material was found to be 0.0016 Pa at 25 °C.
Supporting Study: Hoffman (1988)
The vapour pressure of the test material was determined using the gas saturation method and was assessed according to OECD 104 and in compliance with GLP. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
A nitrogen stream saturated with the test material flowed through cold trapping apparatus. The test material trapped was analysed using HPLC and the vapour pressure calculated according to the ideal gas equation.
Under the conditions of this study the average vapour pressure for the test material is 8.98 x 10^-4 mm Hg.
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