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EC number: 701-396-4 | CAS number: -
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 May 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- GLP guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- adopted in 2006
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- adopted in 2009
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Hess. Ministerium für Umwelt, Energie, Landwirtschaft und Verbraucherschutz, Wiesbaden, Germany
- Type of method:
- effusion method: isothermal thermogravimetry
- Key result
- Temp.:
- ca. 20 °C
- Vapour pressure:
- ca. 0 Pa
- Remarks on result:
- other:
- Remarks:
- value determined based on an extrapolation and fitting to regression curve
Reference
Results:
Using the temperature program below 160 °C no significant weight loss was observed (weight loss ˂ 1 μg/min) or the weight loss was indeed recorded, but the slope of the weight loss was not stable and not reproducible. The results could not be evaluated, due to the test item properties (assumed decomposition of the impurities). The vapour pressure cannot be determined with the sufficient accuracy under these conditions.
The evaluation of the vapour pressure was done applying temperatures between 170 °C and 200 °C.
After extrapolation of the curve to 20 °C and fitting this value in the regression curve, a vapour pressure of:
3.0E-8 Pa was obtained (temperature program 160 °C to 200 °C, evaluation at 170 °C to 200 °C).
Conclusion:
The isothermal thermogravimetric effusion method was chosen for the determination of the vapour pressure of LZ 53478.
This method is suitable for substances with vapour pressures as low as 1E-10 Pa and with purity as close as possible to 100% to avoid the misinterpretation of measured weight losses.
The vapour pressure of the test item was determined:
at 20 °C: 3.0E-8 Pa (mean of three determinations).
Description of key information
3.0E-8 Pa at 20.0 °C (OECD Guideline 104 (Vapour Pressure Curve), EU Method A.4 (Vapour Pressure), isothermal thermogravimetric effusion method)
Key value for chemical safety assessment
- Vapour pressure:
- 0 Pa
- at the temperature of:
- 20 °C
Additional information
Value determined based on an extrapolation and fitting to regression curve.
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