Dipotassium hexachloropalladate

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This is a experimental study performed following standard laboratory operating procedures, of unknown GLP status, minor restrictions in the design and/or reporting but otherwise acceptable for assessment.

Qualifier:

no guideline followed

Principles of method if other than guideline:

Test performed following laboratory SOP 1180L 5.00

GLP compliance:

not specified

Type of method:

Laser scattering/diffraction

Type of distribution:

volumetric distribution

Percentile:

D10

Mean:

15.13 µm

St. dev.:

0

Remarks on result:

other:

Remarks:

Standard deviation not reported.

Percentile:

D50

Mean:

35.87 µm

St. dev.:

0

Remarks on result:

other:

Remarks:

Standard deviation not reported.

Percentile:

D90

Mean:

58.49 µm

St. dev.:

0

Remarks on result:

other:

Remarks:

Standard deviation not reported.

Key result

Percentile:

other: mean

Mean:

35.3 µm

St. dev.:

0

Remarks on result:

other:

Remarks:

Standard deviation not determined.

Summary of results table:

x	0.04	0.10	1.00	2.00	4.00	6.00	10.00	15.00	20.00	32.00
Q3	0.00	0.20	2.68	3.36	4.16	4.83	6.16	9.85	16.46	40.85
x	63.00	100.0	150.0	250.0	500.0	710.0	1000.0	1400.0	2000.0	2500.0
Q3	93.87	100.00	100.00	100.00	100.00	100.00	100.00	100.00	100.00	100.00

x : diameter / microns Q3 : cumulative values ​​/ % Q3 : density distribution

Conclusions:

The 10th, 50th and 90th percentile particle sizes for dipotassium hexachloropalladate were 15.13, 35.87 and 58.49 μm, respectively, with a mean particle size of 36.30 μm.

Executive summary:

This is a experimental study performed to the laboratory standard operating procedure, of unknown GLP status, minor restrictions in the design and/or reporting but otherwise acceptable as the key study for this endpoint. The 10th, 50th and 90th percentile particle sizes for dipotassium hexachloropalladate were 15.13, 35.87 and 58.49 μm, respectively, with a mean particle size of 36.30 μm.

.

Reference 2

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This is a experimental study performed following standard laboratory operating procedures, of unknown GLP status, minor restrictions in the design and/or reporting but otherwise acceptable for assessment.

Qualifier:

no guideline followed

Principles of method if other than guideline:

Test performed following laboratory SOP 1180L 5.00

GLP compliance:

not specified

Type of method:

Laser scattering/diffraction

Type of distribution:

volumetric distribution

Percentile:

D10

Mean:

14.9 µm

St. dev.:

0

Remarks on result:

other:

Remarks:

Standard deviation not reported.

Percentile:

D50

Mean:

32.93 µm

St. dev.:

0

Remarks on result:

other:

Remarks:

Standard deviation not reported.

Percentile:

D90

Mean:

55.11 µm

St. dev.:

0

Remarks on result:

other:

Remarks:

Standard deviation not reported.

Key result

Percentile:

other: mean

Mean:

34.01 µm

St. dev.:

0

Remarks on result:

other:

Remarks:

Standard deviation not reported.

Summary of results table:

x	0.04	0.10	1.00	2.00	4.00	6.00	10.00	15.00	20.00	32.00
Q3	0.00	0.00	1.04	2.01	3.16	4.10	5.81	10.11	18.24	47.54
x	63.00	100.0	150.0	250.0	500.0	710.0	1000.0	1400.0	2000.0	2500.0
Q3	95.49	100.00	100.00	100.00	100.00	100.00	100.00	100.00	100.00	100.00

x : diameter / microns Q3 : cumulative values ​​/ % Q3 : density distribution

Conclusions:

The 10th, 50th and 90th percentile particle sizes for dipotassium hexachloropalladate were 14.90, 32.93 and 55.11 μm, respectively, with a mean particle size of 34.01 μm.

Executive summary:

This is a experimental study performed to the laboratory standard operating procedure, of unknown GLP status, minor restrictions in the design and/or reporting but otherwise acceptable as the key study for this endpoint. The 10th, 50th and 90th percentile particle sizes for dipostassium hexachloropalladate were 14.90, 32.93 and 55.11 μm, respectively, with a mean particle size of 34.01 μm.

Description of key information

The average 10th, 50th and 90th percentile particle sizes for dipotassium hexachloropalladate were 15.02, 34.40 and 56.80 μm, respectively. The average mean particle size was 35.16 μm.

Additional information

CILAS (2008) conducted particle size measurements for a sample of dipotassium hexachloropalladate. Although the study was non-GLP, the method used is considered to be suitable for the substance. The average 10th, 50th and 90th percentile particle sizes for dipotassium hexachloropalladate were 15.02, 34.40 and 56.80 μm, respectively. The average mean particle size was 35.16 μm.

The dustiness of dipotassium hexachloropalladate was tested in a modified Heubach procedure according to the guideline DIN 55992-1:2006 (Selck and Parr 2011). The study is non-GLP, but follows a standard guideline and is considered to be reliable. The total dustiness of dipotassium hexachloropalladate was determined to be 588.08 mg/g. The inhalable fraction was 344.36 mg/g, the thoracic fraction was 65.74 mg/g and the respirable fraction was 5.90 mg/ g. The Mass Median Aerodynamic Diameter (MMAD) was 25.72 μm with Geometric Standard Deviation of 1.88 μm.