Registration Dossier
Registration Dossier
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EC number: 207-300-2 | CAS number: 460-00-4
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data is from review article or handbook
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- 4-Bromofluorobenzene [CAS No. 460-00-4] Review of Toxicological Literature
- Author:
- : National Toxicology Program (NTP), National Institute of Environmental Health Sciences (NIEHS) National Institutes of Health U.S Department of Health and Human Services
- Year:
- 2 005
- Bibliographic source:
- Toxicological Summary for 4-Bromofluorobenzene [460-00-4] January 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Skin sensitization test was conducted in guinea pigs for 1-Bromo-4-fluorobenzene by Magnusson and Kligman guinea pig maximization test.
- GLP compliance:
- not specified
- Type of study:
- other: Magnusson and Kligman guinea pig maximization test
- Justification for non-LLNA method:
- not specified
Test material
- Reference substance name:
- 1-bromo-4-fluorobenzene
- EC Number:
- 207-300-2
- EC Name:
- 1-bromo-4-fluorobenzene
- Cas Number:
- 460-00-4
- Molecular formula:
- C6H4BrF
- IUPAC Name:
- 1-bromo-4-fluorobenzene
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material: 1-Bromo-4-fluorobenzene
- Molecular formula: C6H4BrF
- Molecular weight: 175.0 g/mol
- Substance type: organic
- Physical state: liquid
-InChI: 1S/C6H4BrF/c7-5-1-3-6(8)4-2-5/h1-4H
-Smiles: c1(ccc(Br)cc1)F
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: no data
- Vehicle:
- no data
- Concentration / amount:
- No data
Challengeopen allclose all
- Route:
- other: no data
- Vehicle:
- no data
- Concentration / amount:
- No data
- No. of animals per dose:
- No data
- Details on study design:
- No data
- Challenge controls:
- No data
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Clinical observations:
- mild sensitizer
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Clinical observations: mild sensitizer.
Any other information on results incl. tables
Produced a 20% sensitization rate.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material 1-Bromo-4-fluorobenzene (CAS No: 460-00-4) was observed to be sensitizing on guinea pig skin.
- Executive summary:
The Magnusson and Kligman guinea pig maximization test was conducted for test chemical1-Bromo-4-fluorobenzene (CAS No: 460-00-4).
Test chemical produced a 20% sensitization rate. Hence1-Bromo-4-fluorobenzene (CAS No: 460-00-4) was considered as mild skin sensitizer to guinea pigs.
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