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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
24-05-2017 – 01-06-2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental test result performed using standard test guidelines
Qualifier:
according to guideline
Guideline:
other: spectrophotometric analytical method
Principles of method if other than guideline:
The water solubility determination of test item 1-bromo-4-fluorobenzene was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101.
GLP compliance:
no
Type of method:
other: spectrophotometric analytical method
Specific details on test material used for the study:
- Name of test material (as cited in study report): 1-Bromo-4-fluorobenzene
- Molecular formula: C6 H4 Br F
- Molecular weight : 175.0g/mol
- Smiles notation: c1(ccc(Br)cc1)F
- InChI: 1S/C6H4BrF/c7-5-1-3-6(8)4-2-5/h1-4H
- Substance type: Organic
- Physical state: Liquid
Key result
Water solubility:
193.878 mg/L
Conc. based on:
test mat.
Temp.:
29 °C
Remarks on result:
other: Moderately soluble in water

Obseravtionn Table:

Sample stirring

Concentration obtained on

Dilution factor

Solubility value obtained

 

the basis of standard curve

 

(mg/L)

24 hour

-

-

-

48 hour

9.9422 mg/L

20

198.844

72 hour

9.4456 mg/L

20

188.912
Conclusions:
The water solubility determination of test item 1-bromo-4-fluorobenzene (CAS No. 460-00-4) was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of 1-bromo-4-fluorobenzene in water was determine to be 193.878 mg/L at 25°C.
Thus 1-bromo-4-fluorobenzene (CAS No. 460-00-4) is considered to be moderately soluble.
Executive summary:

The water solubility determination of test item 1-bromo-4-fluorobenzene (CAS No. 460-00-4) was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of 1-bromo-4-fluorobenzene in water was determine to be 193.878 mg/L at 25°C.

Thus 1-bromo-4-fluorobenzene (CAS No. 460-00-4) is considered to be moderately soluble.

Description of key information

The water solubility determination of test item 1-bromo-4-fluorobenzene (CAS No. 460-00-4) was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of 1-bromo-4-fluorobenzene in water was determine to be 193.878 mg/L at 25°C.

Thus 1-bromo-4-fluorobenzene (CAS No. 460-00-4) is considered to be moderately soluble.

Key value for chemical safety assessment

Water solubility:
193.878 mg/L

Additional information

The water solubility determination of test item 1-bromo-4-fluorobenzene (CAS No. 460-00-4) was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of 1-bromo-4-fluorobenzene in water was determine to be 193.878 mg/L at 25°C. Thus 1-bromo-4-fluorobenzene (CAS No. 460-00-4) is considered to be moderately soluble.

Data from various authoritative databases and handbooks suggests that the estimated water solubility of 1 -bromo-4 -fluorobenzene at 25 deg C was 136.4 mg/l. This value indicates that the test chemical is moderately soluble in water.

Thus on the basis of above data, chemical consider to be moderately soluble in water.