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EC number: 255-138-6 | CAS number: 40910-49-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Elintaal F was tested in a skin irritation study with rabbits, performed equivalent to OECD 404 test guideline. The in vitro skin irritation test was conducted according to OECD 439 guideline and GLP principles.
Elintaal F was tested in an eye irritation study with rabbits, performed equivalent to OECD 405 test guideline.
Based on this, Elintaal is considered skin irritating and not irritating to the eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
Elintaal F was tested in a skin irritation study with rabbits, performed equivalent to OECD 404 test guideline.
Elintaal F caused moderate skin irritation 48 hours after patch removal. Its dermal effects consisted of very slight or well-defined erythema, very slight ischemia, slight or distinct scaliness and very slight or slight edema.
As the observation period was limited to 48 hours after patch removal and no reversibility had been observed, an in vitro skin irritation study was performed.
In an in vitro skin irritation test using a human skin model ( EPISKIN Small Model), the influence of the test substance on the viability of human skin was tested. The test substance (25μl) was applied directly to 0.38 cm2cultured skin.
After 15 minutes, the substance was removed and cells were cultured for 42 hours. Elintaal was checked for possible direct MTT reduction by adding the test substance to MTT medium. Because no colour change was observed it was concluded that Elintaal did not interact with MTT.
The viability of the cells was tested by reduction of MTT. Survival of unexposed skin was set at 100%, the positive control had a mean cell viability of 13% whereas the test substance showed cell viability of 25%. Since the mean relative tissue viability after exposure to the test substance was below 50%, it can be concluded that Elintaal is irritating in the in vitro skin irritation test.
Based on the in vivo study, it can be concluded that Elintaal is not corrosive. Based on the in vitro study, it can be concluded that Elintaal should be
classified as skin irritation cat.2 and should be labelled with H315: Causes skin irritation.
Eye irritation:
Elintaal F was tested in an eye irritation study with rabbits, performed equivalent to OECD 405 test guideline.
The test substance caused slight redness of the conjunctivae in 3 out of 6 rabbits. The effects were fully reversible after 7 days. No effects on cornea, iris and chemosis were observed.
Based on the results, Elintaal F does not have to be classified.
Justification for selection of skin irritation / corrosion endpoint:
One in vivo and one in vitro study on the substance is available.
Justification for selection of eye irritation endpoint:
One in vivo study on the substance is available.
Effects on skin irritation/corrosion: irritating
Justification for classification or non-classification
Based on the results, Elintaal should be classified as skin irritation cat.2 and should be labelled with H315: Causes skin irritation according to Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures.
Elintaal does not have to be classified for eye irritation according to Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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