Registration Dossier
Registration Dossier
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EC number: 226-164-5 | CAS number: 5307-14-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is fom peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Dominant lethal mutagenicity study on hair dyes
- Author:
- C. Burnett, R. Loehr & J. Corbett
- Year:
- 1 977
- Bibliographic source:
- Journal of Toxicology and Environmental Health, 2:3, 657-66, 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- The test material was tested for percutaneous toxicity in groups of four to eight New Zealand rabbits (1.7-2.5 kg). The rabbits were shaved closely the day before the materials were applied in 10 ml of an oxidation-type hair dye base. The period of application was 24 hr.
- GLP compliance:
- not specified
- Test type:
- other: no data
Test material
- Reference substance name:
- 2-nitro-p-phenylenediamine
- EC Number:
- 226-164-5
- EC Name:
- 2-nitro-p-phenylenediamine
- Cas Number:
- 5307-14-2
- Molecular formula:
- C6H7N3O2
- IUPAC Name:
- 2-nitrobenzene-1,4-diamine
- Reference substance name:
- 2 nitro p phenylene diamine
- IUPAC Name:
- 2 nitro p phenylene diamine
- Details on test material:
- - Name of test material (as cited in study report):2 nitro p phenylene diamine - Substance type:Organic- Physical state:Solid
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALSSource: No dataAge at study initiation: No dataWeight at study initiation: 1.7-2.5 kg Fasting period before study: No data Housing: No dataDiet (e.g. ad libitum): No dataWater (e.g. ad libitum): No dataAcclimation period: No data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- The rabbits were shaved closely the day before the materials were applied in 10 ml of an oxidation-type hair dye base
- Duration of exposure:
- 24 hrs
- Doses:
- 5000 mg/kg (as 10 ml)
- No. of animals per sex per dose:
- 4-8
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- The test material was tested for percutaneous toxicity in groups of four to eight New Zealand rabbits (1.7-2.5 kg). The rabbits were shaved closely the day before the materials were applied in 10 ml of an oxidation-type hair dye base. The period of application was 24 hr.The LD50 for the test material in rabbits is > 5000mg/kg
- Executive summary:
The test material was tested for percutaneous toxicity in groups of four to eight New Zealand rabbits (1.7-2.5 kg). The rabbits were shaved closely the day before the materials were applied in 10 ml of an oxidation-type hair dye base. The period of application was 24 hr.
The LD50 for the test material in rabbits is > 5000mg/kg
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