Registration Dossier
Registration Dossier
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EC number: 223-098-9 | CAS number: 3734-67-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from WHO Technical Report
Data source
Reference
- Reference Type:
- publication
- Title:
- SUMMARY OF TOXICOLOGICAL DATA OF CERTAIN FOOD ADDITIVES – RED 2G
- Author:
- Food and Agriculture Organization of the United Nations World Health Organization. The data contained in this document were examined by the Joint FAO/WHO Expert Committee on Food Additives, Geneva, 18-27 April 1977
- Year:
- 1 977
- Bibliographic source:
- Twenty-first Report of the Joint FAO/WHO Expert Committee on Food Additives, Geneva, 1977, WHO Technical Report Series No. 617
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- To estimate the acute oral toxicity of Acid Red 1
- GLP compliance:
- not specified
- Test type:
- other: No data
Test material
- Reference substance name:
- Disodium 5-acetylamino-4-hydroxy-3-(phenylazo)naphthalene-2,7-disulphonate
- EC Number:
- 223-098-9
- EC Name:
- Disodium 5-acetylamino-4-hydroxy-3-(phenylazo)naphthalene-2,7-disulphonate
- Cas Number:
- 3734-67-6
- Molecular formula:
- C18H15N3O8S2.2Na
- IUPAC Name:
- disodium 5-acetamido-4-hydroxy-3-(phenyldiazenyl)naphthalene-2,7-disulfonate
- Reference substance name:
- RED 2G [Acid Red 1]
- IUPAC Name:
- RED 2G [Acid Red 1]
- Details on test material:
- - Name of test material (as cited in study report):RED 2G [Acid Red 1]- Molecular formula (if other than submission substance):C18H13N308S2Na2- Molecular weight (if other than submission substance):509.43- Substance type:Organic- Physical state:Solid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Gross pathology:
- Histological studies in rats showed extensive renal necrosis.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- In an acute oral study in rats, the acute oral LD50 for RED 2G was found to be greater than 5000mg/kg
- Executive summary:
Acute Oral studies were carried out on rats, guinea pigs and rabbits. Rats were administered RED 2G orally through gavage and toxic signs were observed. Histological studies in rats showed extensive renal necrosis.
The acute oral LD50 for RED 2G was found to be greater than 5000mg/kg
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