Registration Dossier
Registration Dossier
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EC number: 222-148-7 | CAS number: 3371-33-3
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01 Mar 2018 - 06 Jun 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 187
- Principles of method if other than guideline:
- recognized international standard
- GLP compliance:
- yes
- Type of method:
- Laser scattering/diffraction
- Type of particle tested:
- primary particle
- Type of distribution:
- volumetric distribution
Test material
- Reference substance name:
- 1-(3,5-dihydroxyphenyl)-2-[[2-(4-hydroxyphenyl)-1-methylethyl]amino]ethan-1-one hydrobromide
- EC Number:
- 222-148-7
- EC Name:
- 1-(3,5-dihydroxyphenyl)-2-[[2-(4-hydroxyphenyl)-1-methylethyl]amino]ethan-1-one hydrobromide
- Cas Number:
- 3371-33-3
- Molecular formula:
- C17H19NO4.BrH
- IUPAC Name:
- 1-(3,5-dihydroxyphenyl)-2-{[1-(4-hydroxyphenyl)propan-2-yl]amino}ethan-1-one hydrobromide
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
Particle sizeopen allclose all
- Key result
- Percentile:
- D50
- Mean:
- 134.46 µm
- Remarks on result:
- other: Mean of three measurements 129.391 µm, 135.130 µm and 138.871 µm
- Percentile:
- D10
- Mean:
- 11.02 µm
- Remarks on result:
- other: Mean of three measurements 10.464 µm, 11.154 µm and 11.456 µm
- Percentile:
- D90
- Mean:
- 351.11 µm
- Remarks on result:
- other: Mean of three measurements 346.163 µm, 351.574 µm and 355.589 µm
Applicant's summary and conclusion
- Conclusions:
- The L10 D (v, 0.1) was determined to be 11.02 µm, the L50 D (v, 0.5) was determined to be 134.46 µm and the L90 D (v, 0.9) was determined to be 351.11 µm.
The test item contains many particles >> 2 mm that are already retained in the primary screen (1.6 mm) and can’t be dispersed.
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