Registration Dossier
Registration Dossier
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EC number: 406-370-3 | CAS number: 58890-25-8 MDI/CHA
Endpoint summary
Administrative data
Description of key information
In an acute oral and in an acute dermal toxicity study the LD50 was determined to be >2000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute oral:
Ten male and ten female rats received a single dose of 2000 mg/kg bw. No deaths and no signs of toxicity were observed.
The result of the study was obtained from ELINCS notification 91-06-0295-00 (10-year rule). Information from migrated NONS file, as per inquiry number 06-2119971773-26-0000, permission to refer granted by ECHA.
Acute dermal:
MDI/CHA was administered by dermal application, to five rats of each sex, at 2000 mg/kg body weight. No animals died during the study.
The treated skin surface of the animals showed spots with crusts in 2 females on day 8 and 1 female on day 15. All animals showed body weight gain over the study period. No abnormalities were found at macroscopic post mortem examination of the animals.
Justification for classification or non-classification
Based on the results, MDI/CHA does not have to be classified for acute oral and acute dermal toxicity according to Regulation (EC) No 1272/2008 and its amendments.
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