Registration Dossier
Registration Dossier
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EC number: 700-413-2 | CAS number: 6331-96-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-amino-4,5-dichlorobenzene-1-sulfonic acid
- EC Number:
- 700-413-2
- Cas Number:
- 6331-96-0
- Molecular formula:
- C6 H5 Cl2 N O3 S
- IUPAC Name:
- 2-amino-4,5-dichlorobenzene-1-sulfonic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- other: Test item was mixed to a paste with sterile water
- Controls:
- not required
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- Approximately 1, 24, 48 and 72 hours after the end of the 4 hour exposure period.
- Number of animals:
- 3
Results and discussion
In vivo
Results
- Irritation parameter:
- other: edema or oedema
- Basis:
- other: individual animal 1, 2 or 3
- Time point:
- other: all time points
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effect observed
- Remarks on result:
- other: There was no indication of a local reaction to the skin neither of a systemic effect.
- Other effects:
- No erythema or oedema was recorded during the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Executive summary:
There was no indication of a local reaction to the skin neither of a systemic effect. These results indicate that the test item, Dichlororthanilsäure, has no irritant effect on the skin of the rabbit following a 4 hour dermal exposure period.
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