Registration Dossier
Registration Dossier
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EC number: 207-838-8 | CAS number: 497-19-8
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Remarks:
- other: assessment of published data
- Type of information:
- other: assessment of available data
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliability score 2 on the basis of the weight of evidence found during review of public documents relating to toxicity of sodium carbonate
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Compilation and assessment of available published data for repeat dose toxicity
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium carbonate
- EC Number:
- 207-838-8
- EC Name:
- Sodium carbonate
- Cas Number:
- 497-19-8
- Molecular formula:
- CH2O3.2Na
- IUPAC Name:
- disodium carbonate
Constituent 1
Test animals
- Species:
- other: humans
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- > 10 mg/m³ air
- Based on:
- other: human experience
- Sex:
- male/female
- Basis for effect level:
- other: No actual effect level value has been derived for human inhalation. Since there is no evidence of dust toxicity in humans, a value which is equivalent to nuisance dust has been assigned.
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Executive summary:
Sodium carbonate is produced on all continents of the world and the global number of production sites is estimated to be 50-70. The total world demand of sodium carbonate in 1999 was 33.4 million metric tonnes.
Sodium carbonate is used for the production of glass, soaps and detergents and other chemicals and it also used by the ‘metals and mining’ industry and the ‘pulp and paper’ industry. Sodium carbonate is not only used by industry but is also used by consumers. It may be used directly in solutions of sodium carbonate for soaking of clothes, dishwashing, floor washing and for degreasing operations but it is also present in a large number of consumer products like cosmetics, soaps, scouring powders, soaking and washing powders. Sodium carbonate is also a food additive.
Humans have been regularly exposed to sodium carbonate in various guises over a considerable length of time. There has been no significant reports of ill health caused by inhalation of sodium carbonate either in powder or aerosol form
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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