Acetaldehyde

Repeated dose toxicity: inhalation

Administrative data

Endpoint:

repeated dose toxicity: inhalation

Type of information:

other: hazard assessment report

Adequacy of study:

supporting study

Study period:

-2004

Reliability:

other: reliable hazard assessment report

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

The literature search for the CERI hazard assessment was conducted in April 2002 with the databases including CAS online, HSDB, IRIS, RTECS ,TOXLINE etc. The references were updated when additional information on data source and others were obtained. In April 2004, the status of the risk assessment of acetaldehyde by international organizations was confirmed and any new studies that were critical to determine NOAEL/LOAEL were included in the references.

Data source

Reference

Reference Type:

other: hazard assessment

Title:

Hazard Assessment Report Acetaldehyde

Author:

Chemicals Evaluation and Research Institute (CERI), Japan

Year:

2007

Bibliographic source:

http://www.cerij.or.jp/ceri_en/hazard_assessment_report/yugai_indx_en.htm

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

Acetaldehyde

EC Number:

200-836-8

EC Name:

Acetaldehyde

Cas Number:

75-07-0

Molecular formula:

C2H4O

IUPAC Name:

acetaldehyde

Results and discussion

Target system / organ toxicity

Critical effects observed:

not specified

Any other information on results incl. tables

Table 1: Inhalative repeated dose data [cited from Chemicals Evaluation and Research Institute (CERI), Japan, Hazard assessment on Acetaldehyde 2007, http://www.cerij.or.jp/ceri_en/hazard_assessment_report/yugai_indx_en.htm]

 

Species/strain /sex/age/num berof animals	Period	Dose	Results	Reference
Mouse ICR 4-5 weeks 17-18 animals /group	5days 3hours/day	0, 324 mg/m^3 (0, 180ppm)	324 mg/m3 Decrease in bactericidal activity of alveolar macrophages by 11.2%, no change in mortality by streptococcal infection	Aranyi et al., 1986
Rat SD Male Age unknown 6 animals /group	22days	750-2,500 mg/m^3	No death following phased increases of exposure concentrations. The authors consider that the reason is due to metabolic adaptation.	Lamboeuf et al. 1987; Latgeet al., 1987
Rat Wistar Male and female 10 animals /group	4 weeks 6 hours/day 5 days/week	0, 400, 1,000, 2,200, 5,000ppm (0, 720, 1,800, 3,950, 9,000 mg/m^3)	400ppmand above Degeneration of the nasal mucosa 1,000ppmand above Male: suppression of body weight gain 2,200ppmand above Hyperplasia andmetaplasiaof the nasal mucosa, increase in mortality 5,000ppm Male: increase in relative weight of lung, decrease in relative weight of liver Female: suppression of body weight gain, decrease in relative weight of liver LOAEL: 400ppm(720 mg/m^3)	Appelman et al., 1982
Rat Wistar Male 10 animals /group	4 weeks 6 hours/day 5 days/week	At basic concentrations of 0, 150, 500ppm(0, 270, 900 mg/m^3) (1) Continuous exposures of 6 hours/day at basic concentrations (2) Exposures at 0, 110, 500ppmfor two periods of 3 hrs/day interrupted by a non-exposure period of 1.5 hrs (3) An exposure profile as (2) superimposed with 5-min periods of six times the basic concentration with a frequency of four peak exposures per 3-hr period.	(1) 6-hr uninterrupted 500ppm: degeneration of the olfactory epithelium NOAEL: 150ppm(270 mg/m^3) (2) 6-hr interrupted 500ppm: degeneration of the olfactory epithelium (3) 6-hr interrupted with peak (6 times the basic concentration) 500ppm:eyeirritation , nervously running around, suppression of body weight gain	Appelman et al., 1986
Rat Wistar Male 12 animals /group	5 weeks 8 hours/day 5 days/week	0, 243ppm(0, 437 mg/m^3)	243ppm Degradation of the olfactory epithelium, inflammation of the nasal mucosa, increases in residual volume and functional residual capacity in pulmonary function test	Saldiva et al., 1985
Syrian hamster 20animals /group	13weeks 6hours/day 5days/week	0, 390, 1,340, 4,560ppm(0, 700, 2,400, 8,200  mg/m^3)	1,340ppm Focal hyperplasia,metaplasiaof the respiratory tract 4,560ppm Suppression of body weigh gain, rhinitis, nasal effusion, salivation, increased relative weights of lung, kidney and heart, degeneration, hyperplasia andmetaplasiaof respiratory and olfactory epithelium of nasal cavity, disappearance of sub epithelial gland of nasal cavity, severe degeneration, hyperplasia andmetaplasiaof the epithelium of nasal turbinate, and focal hyperplasia andmetaplasiaof the larynx, trachea and lung NOAEL: 390ppm(in this assessment)	Kruysse et al., 1975