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EC number: 406-176-9 | CAS number: 79072-96-1 NC-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
LD50 (Oral gavage, rat) > 15000 mg/kg bw.
LD50 (Dermal, 6 hours, guinea pig) > 2000 mg/kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 15 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
An acute oral toxicity study (Bozo Research Centre Inc., 1991) was conducted in rats. Ten male and ten female rats received a single dose (15000 mg/kg bodyweight) by gavage, then were observed for mortality and clinical signs for 14 days. No animals died, and there were no abnormal findings at necropsy.
An acute dermal toxicity study was conducted (Batelle Institut E.V., Frankfurt) in Albino guinea pigs according to OECD test guideline 402. Five males and five females were dosed at 2000 mg/kg with the test material in olive oil vehicle; the test material was applied and the test site secured with an occlusive dressing for 6 hours. No animals died, and no signs of local or systemic toxicity were observed.
Justification for classification or non-classification
The LD50 for both oral and dermal exposure were determined to be greater than 2000 mg/kg for acute exposure; on this basis NC-4 does not trigger the criteria for classification as acutely toxic, according to EC Regulation 1272 /2008.
In both the oral and dermal tests, animals were dosed at or above the limit dose, and no signs of local or systemic toxicity were observed. As no abormalities were seen in the necropsy phase of either study, it may be concluded that neither of these exposure routes display Specific Target Organ Toxicity (STOT Acute) and so classification for this hazard should not be applied. As there is no data concerning STOT following inhaled exposure to NC-4, the overall classification regarding STOT Acute is inconclusive.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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