Registration Dossier
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EC number: 211-754-7 | CAS number: 693-57-2
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
ErC50 (0 - 72 h) = 20 mg/L; EyC50 (0 - 72 h) = 7.0 mg/L; EbC50 (0 - 72 h) =7.4 mg/L 72 hour LOEC = 10.2 mg/L; 72 hour NOEC = 3.05 mg/L, OECD 201, EU Method C.3, US OPPTS 850.5400 and EPA OPP 122-2, Vryenhoef 2008
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 20 mg/L
- EC10 or NOEC for freshwater algae:
- 3.05 mg/L
Additional information
The effect of the test material on the growth of Pseudokirchneriella subcapitata was investigated in accordance with the standardised guidelines OECD 201, EU Method C.3, US CFR Title 40 Part 797 Section 1050, US EPA Pesticide Assessment Guidelines, Sub-Division J, Section 122-2 and the US EPA Draft Ecological Effects Test Guideline OPPTS 850.5400.
The effects on growth of were investigated over a 96 -hour period and gave an ErC50 (0 - 72 h) of 22 mg/L, an EyC50 (0 - 72 h) of 8.1 mg/L and an EbC50 (0 - 72 h) of 8.5 mg/L.
The No Observed Effect Concentration at 72 hours based on growth rate, yield and biomass integral was 3.61 mg/L. Correspondingly the Lowest Observed Effect Concentration based on growth rate, yield and biomass integral was 11.6 mg/L.
Based on the geometric mean measured test concentrations the ErC50 (0 - 72 h) value was 20 mg/L; the EyC50 (0 - 72 h) value was 7.0 mg/L and the EbC50 (0 - 72 h) value was 7.4 mg/L.
The Lowest Observed Effect Concentration (0 - 72 h) based on growth rate, yield and biomass integral was 10.2 mg/L, and the No Observed Effect Concentration (0 - 72 h) was 3.05 mg/L.
The study was performed under GLP in line with accepted standardised guidelines with a high standard of reporting. The study was assigned a reliability score of 1 according to the principles for assessing data quality set out in Klimisch (1997) and is considered suitable for assessment as an accurate reflection of the test material.
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