Registration Dossier
Registration Dossier
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EC number: 204-984-4 | CAS number: 130-26-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Primary irritant dermatitis from topical clioquinol
- Author:
- Matti Kero1,*, Matti Hannuksekla1, Aslak Sothman2
- Year:
- 1 979
- Bibliographic source:
- Contact Dermatitis Volume 5, Issue 2, pages 115–117,
Materials and methods
- Principles of method if other than guideline:
- Primary irritation effets due to from topical clioquinol
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Clioquinol
- EC Number:
- 204-984-4
- EC Name:
- Clioquinol
- Cas Number:
- 130-26-7
- Molecular formula:
- C9H5ClINO
- IUPAC Name:
- 5-chloro-7-iodoquinolin-8-ol
Constituent 1
Test animals
- Species:
- human
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Amount / concentration applied:
- 3% large crystal
- Duration of treatment / exposure:
- 2years
- Number of animals:
- seven patients
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks on result:
- other: irritant
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The clioquinol cause irritation to the human skin
- Executive summary:
During the 2-year period seven patients were studied with primary irritant dermatitis from topical preparations containing clioquinol. During the same period contact hypersensitivity to the compound was recorded in 35 eczema patients. Six of the seven patients with clioquinol irritancy had used creams containing 3% large crystal clioquinol and fluorinated steroids.
One patient had used 6% small crystal clioquinol cream. Challenge tests with 3% small crystal and large crystal clioquinol creams showed that crystal size did not affect the appearance of the appearance of irritant dermatitis.
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