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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No GLP and guideline compliant study.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1964
Report date:
1964

Materials and methods

Principles of method if other than guideline:
No data about the method available
GLP compliance:
not specified
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
4-isopropylbenzaldehyde
EC Number:
204-516-9
EC Name:
4-isopropylbenzaldehyde
Cas Number:
122-03-2
Molecular formula:
C10H12O
IUPAC Name:
4-(propan-2-yl)benzaldehyde
Test material form:
other: liquid

Test animals

Species:
rat
Strain:
Osborne-Mendel
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: No data
- Age at study initiation: Young adult
- Weight at study initiation: No data
- Fasting period before study: 18 hr


Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
No data
Doses:
No data
No. of animals per sex per dose:
5 animals
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No data
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs, body weight,organ weights
Statistics:
LD50 was computed by the method of Litchfield & Wilcoxon.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 390 mg/kg bw
Based on:
test mat.
95% CL:
> 1 140 - < 1 700
Mortality:
Mortality occured after 4hr - 10 days (most deaths within 2 days).
Clinical signs:
other: Depression within 1 hr after treatment, porphyrin-like deposit around eyes and nose.
Gross pathology:
Gross pathology showed discoloured live, irritated gastro- intestinal tract, stomach haemorrhage, yellowish material attached to the intestines.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The test substance is harmful if swallowed. The LD50 value was determined to be 1390 mg/kg (male/female).
Executive summary:

The acute oral toxicity test was conducted with 10 young adult Osborne-Mendel rats evenly divided by sex. The animals were fasted approximately 18 hours prior to treatment. All doses were given by intubation. The animals were maintained under close observation for recording toxic signs and time of death. Such observation was continued until animals appeared normal and showed weight gain. The usual observation period was 2 weeks. Following observations were made: Depression within 1 hour after treatment, scrawny appearance, porphyrin-like deposit around eyes and nose. Gross pathology examinations showed discoloured liver, irritated gastro- intestinal tract, stomach haemorrhage, yellowish material attached to the intestines.

The LD50 value was determined to be1390 mg/kg (male/female).