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EC number: 939-595-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Apr 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study design equivalent to OECD 401 with sufficient reporting
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- performed before GLP guidelines
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- potassium diethyl octylphosphonate ethyl octylphosphonate
- EC Number:
- 939-595-5
- IUPAC Name:
- potassium diethyl octylphosphonate ethyl octylphosphonate
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: Hoe WISKf(SPF71)
- Source: Hoechst AG Kastengrund - SPF breed
- Weight at study initiation: 160-180 g (female); (mean = 168.9 g; s = ± 5.99; n = 50)
- Fasting period before study: 16 hours before and 2 hours after application
- Diet: Altromin 1324 (Altromin GmbH, Lage/Lippe), ad libitum
- Water: Tap water ad libitum
ENVIRONMENTAL CONDITIONS
- Housing: in groups, in plastic cages, wood shavings
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25% (w/v) - Doses:
- 630 mg/kg bw
1250 mg/kg bw
1800 mg/kg bw
2500 mg/kg bw
5000 mg/kg bw - No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations after application / Weighing once weekly
- Necropsy of survivors performed: yes - Statistics:
- Probit analysis (method by Linder and Weber);
Confidence limits according to Fieller
Results and discussion
- Preliminary study:
- Preliminary experiments showed higher sensitiveness for females. Therefore only females were used for the main study.
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 010 mg/kg bw
- 95% CL:
- > 1 510 - < 2 790
- Mortality:
- Sex: female, Dose: 630 mg/kg bw, Mortality rate: 1 / 10
Sex: female, Dose: 1250 mg/kg bw, Mortality rate: 2 / 10
Sex: female, Dose: 1800 mg/kg bw, Mortality rate: 3 / 10
Sex: female, Dose: 2500 mg/kg bw, Mortality rate: 6 / 10
Sex: female, Dose: 5000 mg/kg bw, Mortality rate: 10 / 10 - Clinical signs:
- other: Mortally poisened animals died within 2 h -4 days after application. Following symptoms were observed: abnormal breathing, crouched posture Surviving animals showed no symptoms.
- Gross pathology:
- Dissection of rats killed at the end of the observation period revealed no macroscopic findings.
Necropsy of the deceased animals revealed following macroscopic findings: red spots in the lungs, gastro-intestinal tract injected with blood vessels, red secretion from eyes and nose
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The median lethal dose of Reaction mass of potassium ethyl octylphosphonate and diethyl octylphoshonate was 2010 mg per kg body weight. Based on the result of this study the test substance is not subject for labelling and classification according to regulatory requirements.
- Executive summary:
Reaction mass of potassium ethyl octylphosphonate and diethyl octylphosphonate was tested for its acute oral toxicity potential. 10 female rats were treated with doses of 630, 1250, 1800, 2500 or 5000 mg/kg bw and observed for 14 days.
The median lethal dose of Reaction mass of ethyl octylphosphonate and diethyl octylphosphonate (LD50) was 2010 mg per kg body weight. Based on the result of this study the test substance is not subject for labelling and classification according to regulatory requirements.
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