Registration Dossier
Registration Dossier
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EC number: 260-125-3 | CAS number: 56358-10-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH : Please see attached Read Across supporting document in Section 13 which includes the following:
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
3. ANALOGUE APPROACH JUSTIFICATION
4. DATA MATRIX - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Conclusions:
- Based on a read across approach to an analogue substance, the 48 hour EC50 was predicted to be >100mg/L and the 48 hour NOEC was predicted to be 100mg/L.
- Executive summary:
A read across approach to an analogue substance was used to predict the Acute toxicity to Daphnia. The source and the target substance are Solvent Red 19E (N-(2-ethylhexyl)-1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]naphthalen-2-amine) and Solvent Red 500 (N-(2-ethylhexyl)-1-[[3-methyl-4-[(3-ethylphenyl)azo]phenyl]azo]naphthalen-2-amine).
They have the same molecular weight, and the same structure, differing only in the position of the methyl groups on the aromatic rings.
Using QSAR tools, both materials give the same predicted outputs for both water solubility and Aquatic Toxicity.
Experimental data for both materials also confirms that they are both insoluble. The target substance Solvent Red 500 is therefore concluded to have the same aquatic toxicity properties as Solvent Red 19E. See the Read Across justification document for further information.
Reference
Description of key information
Based on a read across approach to an analogue substance, the 48 hour EC50 was predicted to be >100mg/L and the 48 hour NOEC was predicted to be 100mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
