Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-457-6 | CAS number: 107-05-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
- Oral: LD50: 275 mg/kg bw (180 — 526, 95 % CL) for the rat (OECD TG 401); study Henck (1980)
- Dermal: LD50: 398 mg/Kg bw for the rabbit (non-guideline test); Dow K-1720-4A
- Inhalation: LC50: 2900 mg/kg bw for the male guinea pig (generally compliant to OECD TG 403); study Lu (1982)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 275 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 2 900 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 398 mg/kg bw
Additional information
- oral toxicity: The value for the key parameter of 275 mg/kg bw (180 — 526, 95 % CL) is based on the lowest observed value in a study considered to be reliable Henck (1980) in the rat. The other studies including one for mice (Lu, 1982) are all unreliable due to very limited details on methods and results. In addition the values stated there are higher (Lu 1982, rats: 460 mg/Kg, Lu 1982, mice: 425 mg/Kg, Smyth 1948, rats: 700 mg/Kg) indicating that the key value is set at a conservative benchmark. Clinical signs are lethargy, diarrhea, hind limb paralysis, piloerection and convulsions severity of clinical signs is dose dependent. As adverse effects based on histology irritation base lesions like stomach thickening and roughening of nonglandular squamous epithelium, focal thickening of nonglandular stomach wall, erosion of nonglandular epithelium and finally perforated ulcers were found at very high doses at the portal of entry, cloudy swelling and focal necrosis is found in liver and kidneys. In addition lung pulmonary congestion and edema with hemorrhages into the alveolar spaces are described by (Lu 1982) but it is unclear whether this is a result of aspiration.
- dermal toxicity: The value for the key parameter of 398 mg/kg bw is based on the study Dow K-1720-4A. The study itself is not reliable due to very limited information available on methods and animal husbandry. Nevertheless given the reported good skin absorption of 3 -chloropropene and its fast and thourough distribution throughout the body after absorption, a dermal toxicity comparable to the toxicity via the oral and the inhalation route can be expected, especially as the reported death occured probably due to cyanosis, which was a key adverse effect in the toxicity via the other routes. This assumption supports the LD50 value derived in study Dow K-1720-4A.
- inhalation toxicity: The value for the key parameter of LC50(4h exposure) = 2900 mg/m³ is based on the lowest deducible LC50 value in guinea pigs in a weight of evidence approach combining the following studies: Lu (1982, mouse, rat, guinea pig, rabbit, cat), Quast (1982, rat and mouse) and Adams (1944, rat and guinea pig). The value is an extrapolation of the LC50 of 5800 mg/m³ after 2 h of exposure. Quast is the best reported study and has thereby the highest reliability. But as animals of the dose groups were killed at different time points between 3 and 7 days post treatment, a clear LC50 could not be derived. Nevertheless the approximation of 3100 mg/m³ (1000 ppm) is in good accordance with the value derived from Lu (1982) thereby validating the latter as reliable.
Typical clinical signs after exposure to high (lethal) concentrations are indicative for the irritative action of 3 -chloropropene: closing eyes, pawing, scratching the nose and mouth, lacrimation and salivation. Systemic effects becoming obvious during exposure are comparable to effects seen after oral exposure: hypoactivity, hypopnea, paralysis of hind limbs, drowsiness, unconsciousness, tremor and convulsions.
Guseinov (1983) / (rat, acute inhalative toxicity) reports a NOAEC of 104 mg/m³ based on adverse effects serum choline esterase and neurobehavioural findings (burrow reflex). As the analytical method used in this study is based on colourimetric assays and not described in detail the stated threshold values are highly questionable and regarded as unreliable.
Justification for classification or non-classification
- oral toxicity: 3 -chloropropene is moderately toxic via the oral route based on systemic effects that lead to respiratory arrest. Classification as Category III (H301: toxic if swallowed) is considered to be required according to CLP (REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL) as implementation of UN-GHS in the EU.
- dermal toxicity: Using a weight of evidence approach based on results from a non-guideline study and toxicokinetic informations 3 -chloropropene is evaluated to be moderately toxic in contact with the skin.
Classification as Category III (H301: toxic in contact with skin) is considered to be required according to CLP (REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL) as implementation of UN-GHS in the EU.
- inhalation toxicity: 3 -chloropropene is moderately toxic via the inhalation based on systemic effects that lead to respiratory arrest. Classification as Category III (H331: toxic if inhaled) is considered to be required according to CLP (REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL) as implementation of UN-GHS in the EU.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.