Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
222-048-3
CAS no.:
3327-22-8
Index number:
Molecular formula:
C6H15Cl2NO
SMILES:
[Cl-].C[N+](C)(C)CC(O)CCl
InChI:
InChI=1/C6H15ClNO.ClH/c1-8(2,3)5-6(9)4-7;/h6,9H,4-5H2,1-3H3;1H/q+1;/p-1
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
16
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance is suspected of causing cancer and is harmful to aquatic life with long lasting effects.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is toxic to aquatic life with long lasting effects.

Breakdown of all 856 C&L notifications submitted to ECHA

Carc. 2 H351 Harmonised Classification
Aquatic Chronic 2 H411
Aquatic Chronic 3 H412 Harmonised Classification
Skin Irrit. 2 H315
Eye Irrit. 2 H319
STOT SE 3 H335
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • C
Suspected to be Carcinogenic (Harmonised C&L).

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 16 active registrations under REACH, 2 Joint Submission(s) and 1 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 10 - 100 tonnes per year.

This substance is used by consumers, in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: cosmetics and personal care products.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

This substance is used in the following products: textile treatment products and dyes and cosmetics and personal care products.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: paper chemicals and dyes, polymers, textile treatment products and dyes and cosmetics and personal care products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used for the manufacture of: textile, leather or fur and chemicals.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and laboratory work.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), in the production of articles and for thermoplastic manufacture.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not handle until all safety precautions have been read and understood; obtain special instructions before use; use personal protective equipment as required.; avoid release to the environment.

Response statements

In case of incident: If exposed or concerned: get medical advice/attention.

Storage statements

Store this substance locked up.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Ashland Services BV (0311), Noordweg 9 3336 LH Zwijndrecht Netherlands
  • Chemical Inspection & Regulation Service Limited, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemigate Oy, Simpsiöntie 682 62100 Lapua Finland
  • Clariant Produkte (Deutschland) GmbH, Am Unisys-Park 1 65843 Sulzbach am Taunus Germany
  • DOW BENELUX B.V. - OR1, Postbus 48 4530 AA Terneuzen Netherlands
  • Ingredion Germany GmbH, Gruner Deich 110 20097 Hamburg Germany
  • Ingredion UK Ltd, Ingredion House, Manchester Green Business Park 339 Styal Road M22 5LW Manchester United Kingdom
  • Innospec Limited (OR1), Innospec Manufacturing Park Oil Sites Road CH65 4EY Ellesmere Port Cheshire United Kingdom
  • Nalco Europe B.V., Oude Rhijnhofweg 17 2342 BB Oegstgeest Netherlands
  • Nalco Limited, P.O. Box 11, Winnington Avenue, CW8 4DX Northwich, Cheshire United Kingdom
  • RHODIA OPERATIONS, 40 rue de la Haie Coq 93306 AUBERVILLIERS France
  • Ricardo-AEA, Shoreham Technical Centre Old Shoreham Road BN43 8FG Shoreham West Sussex United Kingdom
  • ROQUETTE Frères, 1 rue de la haute loge 62136 LESTREM Cedex France
  • Rudolf GmbH, Altvaterstr. 58 - 64 82538 Geretsried Germany
  • Sachem Europe BV, Van Voordenpark 15 5301 KP Zaltbommel Gelderland Netherlands
  • TSafeE GmbH, Landwehrplatz 6 66111 Saarbruecken Germany

Substance names and other identifiers

(3-Chloro-2-hydroxypropyl) trimethylammonium chloride
Other
(3-chloro-2-hydroxypropyl) trimethylammonium chloride ...%
C&L Inventory
(3-chloro-2-hydroxypropyl); trimethylammonium chloride ...%
Other
(3-chloro-2-hydroxypropyl); trimethylammonium chloride …%
Other
(3-chloro-2-hydroxypropyl)trimethylammonium chloride
EC Inventory, REACH pre-registration, Other
1-Propanaminium, 3-chloro-2-hydroxy-N,N,N-trimethyl-, chloride
Other
1-Propanaminium, 3-chloro-2-hydroxy-N,N,N-trimethyl-, chloride (1:1)
Other
2-Hydroxy-3-chloropropyltrimethylammonium chloride
Other
3-chloro-2-hydroxypropyl
Other
3-chloro-2-hydroxypropyl; trimethylammonium chloride
Other
3-Chloro-2-hydroxypropylammonium chloride
Other
Ammonium, (3-chloro-2-hydroxypropyl)trimethyl-, chloride
Other
Catiomaster C
Other
Dextrosil
Other
Dextrosil KA
Other
Dowquat 188
Other
NT 21
Other
QUAB
Other
Quat 188
Other
Trimethyl(2-hydroxy-3-chloropropyl)ammonium chloride
Other
trimethylammonium chloride
Other
Verolan KAF
Other
(3-chloor-2-hydroxypropyl)trimethylammoniumchloride …% (nl)
C&L Inventory
(3-chlor-2-hidroksipropil)trimetilamonio chloridas ...% (lt)
C&L Inventory
(3-chlor-2-hydroxypropyl)trimethylammoniumchlorid ...% (da)
C&L Inventory
(3-Chlor-2-hydroxypropyl)trimethylammoniumchlorid ... % (de)
C&L Inventory
(3-chlor-2-hydroxypropyl)trimethylamonium-chlorid ...% (cs)
C&L Inventory
(3-hlor-2-hidroksipropil)trimetilamonija hlorīds ...% (lv)
C&L Inventory
(3-kloori-2-hydroksipropyyli)trimetyyliammoniumkloridi …% (fi)
C&L Inventory
(3-klor-2-hydroksypropyl)trimetylammoniumklorid ... % (no)
C&L Inventory
(3-kloro-2-hidroksipropil) trimetilamonijev klorid ... % (sl)
C&L Inventory
(3-kloro-2-hidroksipropil)trimetilamonijev klorid … % (hr)
C&L Inventory
(3-kloro-2-hydroxipropyl)trimetylammoniumklorid ...% (sv)
C&L Inventory
(3-kloro-2-hüdroksüpropüül)trimetüülammooniumkloriid ...% (et)
C&L Inventory
(3-klór-2-hidroxipropil) trimetilammónium-klorid ...% (hu)
C&L Inventory
(3-хлоро-2-хидроксипропил) триметиламониев хлорид...% (bg)
C&L Inventory
2-hydroxy-3-chlór-N,N,N-trimetylpropán-1-amínium-chlorid ... % (sk)
C&L Inventory
chlorek (3-chloro-2-hydroksy-propylo)trimetyloamoniowy...% (pl)
C&L Inventory
chlorure de (3-chloro-2-hydroxypropyl) triméthylammonium ...% (fr)
C&L Inventory
cloreto de (3-cloro-2-hidroxipropil)trimetilamónio a ... % (pt)
C&L Inventory
cloruro de (3-cloro-2-hidroxipropil)trimetilamonio ...% (es)
C&L Inventory
cloruro di (3-cloro-2-idrossipropil)trimetilammonio …% (it)
C&L Inventory
clorură de (3-clor-2-hidroxipropil) trimetilamoniu...% (ro)
C&L Inventory
klorur ta' (3-kloro-2-idrossipropil)trimetilammonju ...% (mt)
C&L Inventory
χλωριούχο (3-χλωρο-2-υδροξυπροπυλο)τριμεθυλαμμώνιο ...% (el)
C&L Inventory
(3-chloro-2-hydroxy-propyl)-trimethyl-azanium chloride
Registration dossier
(3-chloro-2-hydroxypropyl)-trimethylazanium chloride
C&L Inventory
(3-chloro-2-hydroxypropyl)-trimethylazanium;chloride
Other
(3-chloro-2-hydroxypropyl)trimethylazanium chloride
Other
1-Propanaminium, 3-chloro-2-hydroxy-N,N,N-trimethyl-, chloride (9CI)
Registration dossier
3-chloro-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride
C&L Inventory, Registration dossier
3-chloro-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride(3-chloro-2-hydroxypropyl)-trimethylazanium chloride
C&L Inventory, Registration dossier
3-chloro-2-hydroxypropyl) trimethylammonium chloride 65%
C&L Inventory
3-chloro-2-hydroxypropyl)trimethylammonium chloride
C&L Inventory
CHLOROHYDROXYPROPYL TRIMETHYL AMMONIUM CHLORIDE
C&L Inventory
CHPT
Registration dossier
CHPTCHPTAC
Registration dossier
QUAT
Registration dossier
Reagens-S-CFZ
Registration dossier
CHPTAC
Registration dossier
CR-2000
Registration dossier
QUAB-188
Registration dossier
QUAT 188 CATIONIC REAGENT 65 PERCENT ACTIVE
Registration dossier
QUAT 188 CATIONIC REAGENT 69 PERCENT ACTIVE
Registration dossier
101360-39-8
CAS number
Other
115993-13-0
CAS number
Other
126845-69-0
CAS number
Other
1331834-62-8
CAS number
Other
181939-29-7
CAS number
Other
3327-22-8
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other
58128-36-2
CAS number
Other
612-238-00-8
Index number
C&L Inventory
73935-21-4
CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 3 studies submitted
  • 3 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [3]
C Form
Crystalline (67%), Powder (33%) [3]
C Odour
Odourless (100%) [1]
C Substance type
Organic (100%) [3]

Type of Study provided
Studies with data
Key study 2 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 6 studies submitted
  • 3 studies processed
R Melting / freezing point
180.5 °C @ 101.3 - 101.325 kPa [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
180.5 °C

Boiling point

Study results
  • 4 studies submitted
  • 3 studies processed
R Boiling point
190 - 209 °C @ 101.3 - 101.325 kPa [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 7 studies submitted
  • 3 studies processed
R Relative density
1.11 @ 20 °C [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
1.11

Vapour pressure

Study results
  • 5 studies submitted
  • 3 studies processed
R Vapour pressure
0.001 Pa @ 20 °C [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Vapour pressure
0.001 Pa @ 20 °C

Partition coefficient

Study results
  • 4 studies submitted
  • 3 studies processed
R Log Pow
-1.5 @ 25 °C and pH 3.9 - 4 [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Log Kow (Log Pow)
-1.5 @ 25 °C

Water solubility

Study results
  • 4 studies submitted
  • 3 studies processed
R Water solubility (mass/vol.)
835 - 835.2 g/L @ 20 °C and pH 3 - 3.1 [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Water solubility
835.2 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 3 studies submitted
  • 3 studies processed
R Surface tension
72.8 mN/m @ 1 g/L and 20 °C [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Surface tension at 20 °C
72.8 mN/m @ 100 mg/L

Flash point

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 7 studies submitted
  • 2 studies processed
C Interpretation of results
Non flammable (100%) [2]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 3 studies submitted
  • 2 studies processed
C Interpretation of results
Non-explosive (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Hydrolysis

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Half-life for hydrolysis
21 days @ 12 °C

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 25 studies submitted
  • 4 studies processed
C Interpretation of results
Readily biodegradable (50%), Inherently biodegradable (25%), Under test conditions no biodegradation observed (25%) [4]

Type of Study provided
Studies with data
Key study 3
Supporting study 13 1
Weight of evidence 7 1
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)
Type of water
Freshwater (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 5 studies submitted
  • 1 study processed
R Koc
68.8 L/kg @ 20 °C and 50 % organic carbon [1]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
68.8

Henrys law constant (H)

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 51 µg/L (2)
Intermittent releases (freshwater) 1.64 mg/L (2)
Marine water 5.1 µg/L (2)
Intermittent releases (marine water) 164 µg/L (1)
Sewage treatment plant (STP) 103 mg/L (2)
Sediment (freshwater) 116 - 540 µg/kg sediment dw (2)
Sediment (marine water) 54 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 68 - 77 µg/kg soil dw (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 18 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 days) 4.128 g/L [3]
LC100 (4 days) 6.544 g/L [2]
NOEC (4 days) 2.094 g/L [3]

Type of Study provided
Studies with data
Key study 3
Supporting study 11 1
Weight of evidence
Other 3
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
LC50 for freshwater fish
4.128 g/L

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 12 studies submitted
  • 4 studies processed
P/RResults
EC50 (48 h) 164 mg/L [1]
EC50 (24 h) 240.2 mg/L [3]
EC100 (24 h) 650 mg/L [2]
NOEC (48 h) 62.5 mg/L [1]
NOEC (24 h) 36.6 mg/L [3]

Type of Study provided
Studies with data
Key study 4
Supporting study 6 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
164 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 3 studies processed
P/RResults
NOEC (21 days) 510 µg/L [3]
LOEC (21 days) 1.52 mg/L [3]
EC50 (21 days) 1.52 - 4.56 mg/L [2]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater invertebrates
510 µg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 3 studies submitted
  • 3 studies processed
P/RResults
EC50 (72 h) 10 - 10 000 mg/L [5]
NOEC (72 h) 100 mg/L [2]
EC10 (72 h) 360 - 3 200 mg/L [5]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for freshwater algae
3.2 g/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 22 studies submitted
  • 3 studies processed
P/RResults
EC50 (3 h) 2 g/L [3]
EC10 (3 h) 1.032 g/L [2]

Type of Study provided
Studies with data
Key study 3
Supporting study 18 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for microorganisms
1.032 g/L

Sediment toxicity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 5.95 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 703 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 603 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Acute toxicity

Study results
oral
  • 15 studies submitted
  • 5 studies processed
P/RResults
LD50 2 170 - 3 688 mg/kg bw (rat) [7]
LD50 3.2 mL/kg bw (rat) [2]
M/CInterpretations of results
GHS criteria not met [1]

Type of Study provided
oral
Studies with data
Key study 5
Supporting study 9 1
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
dermal
  • 6 studies submitted
  • 4 studies processed
P/RResults
LD50 1 526 - 2 348 mg/kg bw (rat) [6]
M/CInterpretations of results
Study cannot be used for classification [1]

dermal
Studies with data
Key study 4
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 2 213 mg/kg bw
Dermal route:
No adverse effect observed LD50 1 526 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 17 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 5
Supporting study 11
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 19 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 6
Supporting study 12
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 4
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 6 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 1 085 mg/kg bw/day [1]
LOAEL (rat): 1 085 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Study data: inhalation
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study 2
Weight of evidence
Other 2
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed LOAEL 1 085 mg/kg bw/day (subacute, rat)
Dermal route - systemic effects:
Adverse effect observed NOAEL 82 mg/kg bw/day (chronic, mouse)

Genetic toxicity

Study results
Study data: in vitro
  • 36 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 18
Supporting study 12
Weight of evidence
Other 6
Data waiving
no waivers
Study data: in vivo
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to reproduction

Study results
Study data: reproduction
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Study data: developmental
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant