Brief Profile

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Please be aware that the REACH registration parts of this Brief Profile are no longer maintained; they remain frozen as of 19th May 2023. All other data parts (substance identity, C&L, key regulatory lists etc. are up to date).

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
200-879-2
CAS no.:
75-56-9
Index number:
603-055-00-4
Molecular formula:
C3H6O
SMILES:
CC1CO1
InChI:
InChI=1/C3H6O/c1-3-2-4-3/h3H,2H2,1H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
76
Of which contain:
7 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP09) approved by the European Union, this substance is toxic in contact with skin, is toxic if inhaled, may cause genetic defects, may cause cancer, is an extremely flammable liquid and vapour, is harmful if swallowed, causes serious eye irritation and may cause respiratory irritation.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is harmful to aquatic life and causes skin irritation.

Breakdown of all 3188 C&L notifications submitted to ECHA

Muta. 1B H340 Harmonised Classification
Carc. 1B H350 Harmonised Classification
Acute Tox. 4 H302 Harmonised Classification
Eye Irrit. 2 H319 Harmonised Classification
STOT SE 3 H335 Harmonised Classification
Flam. Liq. 1 H224 Harmonised Classification
Acute Tox. 3 H331 Harmonised Classification
Acute Tox. 4 H312
Acute Tox. 3 H311 Harmonised Classification
Skin Irrit. 2 H315
Acute Tox. 4 H332
Flam. Gas 1 H220
Acute Tox. 3 H332
Aquatic Chronic 3 H412
Eye Irrit. 2A H319
https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • C
Officially recognised in the EU as Carcinogenic (Harmonised C&L, Candidate list of SVHCs).
  • C
There is broad agreement in that a majority of data submitters agree this substance is Carcinogenic (100% of REACH registrations).
  • M
Officially recognised in the EU as Mutagenic (Harmonised C&L, Candidate list of SVHCs).
  • M
There is broad agreement in that a majority of data submitters agree this substance is Mutagenic (100% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 327 active registrations under REACH, 2 Joint Submission(s) and 8 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Substance of very high concern (SVHC) and included in the candidate list for authorisation.
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: hydraulic fluids, lubricants and greases, adhesives and sealants, anti-freeze products, coating products, fillers, putties, plasters, modelling clay, finger paints and heat transfer fluids.

Other release to the environment of this substance is likely to occur from: outdoor use, indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: pH regulators and water treatment products, laboratory chemicals and polymers.

This substance is used in the following areas: health services and scientific research and development. This substance is used for the manufacture of: chemicals and .

This substance is used in the following activities or processes at workplace: transfer of chemicals and laboratory work.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

This substance is used in the following products: polymers and laboratory chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers, laboratory work and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, manufacturing of the substance and as an intermediate step in further manufacturing of another substance (use of intermediates).

This substance is used in the following products: polymers, laboratory chemicals and pH regulators and water treatment products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, laboratory work, transfer of substance into small containers, batch processing in synthesis or formulation with opportunity for exposure and mixing in open batch processes.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture, manufacturing of the substance and formulation of mixtures.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, laboratory work, transfer of substance into small containers and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, formulation of mixtures and for thermoplastic manufacture.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: obtain special instructions before use; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; use non-sparking tools; ground and bond container and receiving equipment; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; avoid release to the environment; use personal protective equipment as required.; do not handle until all safety precautions have been read and understood; use explosion-proof equipment (electrical/ventilating/lighting/etc.); keep container tightly closed; avoid breathing the dust, fume, gas, mist, vapours or spray; take actions to prevent static discharges; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: Call a poison center or doctor/physician if you feel unwell. If exposed or concerned: get medical advice/attention. If on skin: wash with soap and water.

Storage statements

Store this substance in a well-ventilated place and Keeping it cool; locked up.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL (OR1), Hermeslaan 7 1831 Diegem Belgium
  • 3M Deutschland GmbH, Carl-Schurz-Strasse 1 41453 Neuss Germany
  • 3M France SAS, 1 Parvis de l'Innovation CS 20203 95006 Cergy-Pontoise Cedex France
  • AFCONA Additives B.V., Amperestraat 34 1704SN Heerhugowaard Netherlands
  • Afton Chemical S.R.L. (Woluwe), Alma Court Lenneke Marelaan, 8 B-1932 St-Stevens-Woluwe Belgium
  • AGC Chemicals Europe, Ltd, World Trade Centre Zuidplein 80 1077XV Amsterdam Netherlands
  • Allnex Belgium NV/SA, Anderlechtstraat 33 1620 Drogenbos Belgium
  • Archroma Germany GmbH, Kasteler Str. 45 65203 Wiesbaden Germany
  • ARCHROMA IBÉRICA, S.L., ZAL-Prat c/Cal Coracero, 46-56 08820 El Prat de Llobregat Spain
  • Arkema Arrmaz, 420 rue Estienne d'Orves 92700 Colombes Cedex France
  • ARKEMA PHOTOCURES, 420 rue d'Estienne d'Orves 92700 Colombes France
  • ARKEMA PHOTOCURES2, 420 rue d'Estienne d'Orves 92700 Colombes France
  • Arrow Regulatory (Ireland) Ltd OR1705, Suite 303 9 Pembroke Street Upper D02 KR83 Dublin 2 Ireland
  • Ashland Industries Nederland BV, Noordweg 9 3336 LH Zwijndrecht Netherlands
  • Ashland Services BV, Noordweg 9 3336 LH Zwijdrecht Netherlands
  • Ashland Services BV (0311), Noordweg 9 3336 LH Zwijndrecht Netherlands
  • Ashland Services BV (OR2), Noordweg 9 3336 LH Zwijndrecht Netherlands
  • B-Lands Consulting (811232-9), World Trade Center, 5 Place Robert Schuman - BP 1510 38025 Grenoble France France
  • B-Lands Consulting (811256-3), World Trade Center 5 Place Robert Schuman - BP 1510 38025 Grenoble France France
  • B.I.G. - OR18020, Technische Schoolstraat 43A 2440 Geel Belgium
  • B.I.G. - OR634, Technische Schoolstraat 43A 2440 Geel Belgium
  • B.I.G. - OR646, Technische Schoolstraat 43A 2440 Geel Belgium
  • Bakelite GmbH, Gennaer Strasse 2-4 D-58642 Iserlohn North Rhine-Westphalia Germany
  • Baker Hughes (Nederland) B.V, p/a Blokmakersweg 10 1786 RC Den Helder Netherlands
  • BASF Agri Production SAS, 21 Rue de la Sauvegarde 69130 Ecully Rhone France
  • BASF Antwerpen N.V., Haven 725, Scheldelaan 600 2040 Antwerpen 4 Antwerpen Belgium
  • BASF Coatings GmbH, Glasuritstrasse 1 Postfach 6123 48136 Münster Nordrhein-Westfalen Germany
  • BASF Construction Additives GmbH , Dr.Albert Frank Strasse 32 83308 Trostberg Germany
  • BASF DOW HPPO Production BVBA, Haven 725 / Scheldelaan 600 2040 Antwerpen 4 Belgium
  • BASF Espanola S.L., Calle Can Ràbia, n. 3-5 8017 Barcelona Spain
  • BASF Health and Care Products France S.A.S., 49, Avenue Georges Pompidou 92593 Levallois-Perret Cedex France
  • BASF Italia S.p.A., Via Marconato 8 20811 Cesano Maderno Italy
  • BASF Personal Care and Nutrition GmbH, Henkelstr. 67 40589 Düsseldorf Germany
  • BASF Polyurethanes GmbH, Elastogranstr. 60 49448 Lemförde Niedersachsen Germany
  • BASF Schwarzheide GmbH, Schipkauer Str. 1 01987 Schwarzheide Brandenburg Germany
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • BD&I_37, rue Omer Lepreux, 92 1081 bruxelles Belgium Belgium
  • Blue Cube Netherlands B.V. – OR1, Axelsedam 3a 4531HH Terneuzen Netherlands
  • BorsodChem Zrt. - OR, Bolyai ter 1. H-3700 Kazincbarcika Hungary
  • BTC Europe GmbH, Rheinpromenade 1 40789 Monheim Germany
  • BYK-Chemie GmbH, Abelstr. 45 DE-46483 Wesel Germany
  • C.S.B. GmbH, Dujardinstr. 5 47829 Krefeld Germany
  • Caplinq Europe B.V., Industrieweg 15E 1566JN Assendelft - Netherlands
  • Carpenter Belgium NV, Wijnendalestraat 171 B-8800 Roeselare Belgium
  • CEPRA srl, Via del Tintoretto, 6/2 40033 Casalecchio di Reno Bo Italy
  • ChampionX Europe B.V., Oude Rhijnhofweg 17 NL-2342BB Oegstgeest Oegstgeest Netherlands
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 D02 Dublin Ireland
  • Chemical Inspection & Regulation Service Limited, Regus Harcourt Centre D02 HW77 Dublin 02 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Unit 1 Ardee Business Park, Hale Street, Co. Louth Ardee Ireland
  • Chemical Inspection & Regulation Service Limited, Regus Harcourt Centre, Dublin, Ireland, D02 HW77 D02 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77, Dublin, Ireland D02 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77, Dublin, Ireland D02 HW77 Dublin Ireland
  • Chemical Inspection & Regulation Service Limited, Regus Harcourt Centre D02 Dublin Ireland
  • Chemical Inspection & Regulation Service Limited, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED (Henan Botai Chemical Building Materials Co., Ltd.), Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemical Inspection & Regulation Service Limited (Shijiazhuang Henggu Jianxin Cellulose Co., Ltd.), Regus Harcourt Centre, Dublin, Ireland, D02 HW77 D02 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED (ZIBO ZHENGDA POLYURETHANE CO., LTD), Regus Harcourt Centre HW77 D02 Dublin Ireland
  • Chemical Inspection & Regulation Service(CIRS) Limited(Tianpu Chemicals Company Limited), Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemreach GmbH, Akazienweg 30 48317 Drensteinfurt Germany
  • Chemservice GmbH - (7AYP), Herrnsheimer Hauptstrasse 1b 67550 Worms Germany
  • Chevron Phillips Chemicals International NV, Airport Plaza, Stockholm Building, Da Vincilaan 19 B-1831 DIEGEM Belgium
  • Chimcomplex S.A. Borzesti, 3, Industriilor Street 601124 Onesti Bacau Romania
  • CHT Germany GmbH, Bismarckstr. 102 72072 Tuebingen Germany
  • CHT ITALIA S. R. L., Via Settembrini, 9 20020 Lainate (MI) Italy
  • CIBA VISION GmbH (OR CVCA), Industriering 1 63868 Großwallstadt Bavaria Germany
  • Cimcool Industrial Products B.V., Schiedamsedijk 20 3134 KK Vlaardingen Netherlands
  • Clariant Ibérica Producción S.A., Avda. Baix Llobregat, 3-5 08970 Sant Joan Despí Barcelona Spain
  • Clariant Produkte (Deutschland) GmbH, August-Laubenheimer-Straße 1 Global Product Stewardship 65929 Frankfurt am Main Germany
  • Clariant SE - GB04, August-Laubenheimer-Strasse 1 65929 Frankfurt am Main Germany
  • Clariant SE - IN20, August-Laubenheimer-Strasse 1 65929 Frankfurt am Main Germany
  • Clariant SE - US01, August-Laubenheimer-Strasse 1 65929 Frankfurt am Main Germany
  • CLiQ SwissTech (Netherlands) B.V., Blauwborgje 31 9747 AC Groningen Groningen Netherlands
  • COATEX SAS, 35 rue AMPERE 69730 GENAY France
  • Colgate Palmolive Services (Poland) Sp.Zo.o / Mexico, ul. Tasmowa 7 02-677 Warsaw Poland
  • Colgate-Palmolive Services (Poland) sp.z o.o. / OR China, ul. Tasmowa 7 02-677 Warsaw Poland
  • Corteva Agriscience Belgium B.V., Rue Montoyer 25, 1000 Brussels Belgium
  • Corteva Agriscience France S.A.S., Immeuble Equinoxe 2 1bis avenue du 8 Mai 1945 78280 Guyancourt France
  • Corteva Agriscience Italia S.r.l., via dei Comizi Agrari 10 26100 Cremona (CR) Italy
  • Corteva Agriscience Spain, S.L.U, Valle de Tamón s/n 33469 Carreño (Asturias) Spain 33469 Carreño (Asturias) Spain
  • Covestro (Netherlands) B.V., Urmonderbaan 22 6167 RD Geleen Netherlands
  • Covestro Deutschland AG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro Deutschland AG OR US_001109, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro Deutschland AG OR US_001257, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • Covestro NV, Haven 507 Scheldelaan 420 2040 Antwerpen Belgium
  • Covestro Procurement Services GmbH & Co. KG, Kaiser-Wilhelm-Allee 60 51373 Leverkusen Germany
  • CRCP GmbH, Am Römerhof 51 60486 Frankfurt am Main Germany
  • Croda EU B.V. (OR1), Westeinde 107 1601 BL Enkhuizen Netherlands
  • Croda EU B.V. (OR2), Westeinde 107 1601 BL Enkhuizen Netherlands
  • Croda EU B.V. (OR3), Westeinde 107 1601 BL Enkhuizen Netherlands
  • CS Regulatory Ireland Ltd. in its legal capacity as Only Representative of LANXESS Canada Co.\Cie, Alexandra House The Sweepstakes D04 C7H2 Dublin Ballsbridge Ireland
  • CS Regulatory Ireland Ltd. in its legal capacity as Only Representative of LANXESS Corporation, Alexandra House The Sweepstakes D04 C7H2 Dublin Ballsbridge Ireland
  • CS Regulatory Ireland Ltd. in its legal capacity as OR for LANXESS Urethanes UK Ltd, Alexandra House The Sweepstakes D04 C7H2 Dublin Ballsbridge Ireland
  • Cytec Industries B.V. OR, Weena 505 3013 AL Rotterdam Netherlands
  • Cytec Industries BV, Weena 505 3013 AL Rotterdam Netherlands
  • Diachem S.p.A., via Tonale 15 24061 Albano S. Alessandro BG Italy
  • Distribution Network s.r.l., via della Sirena, 3 42015 Correggio (RE) Italy
  • Dow Belgium B.V.B.A., Grotesteenweg 214 B-2600 Antwerpen (Berchem) Belgium
  • DOW BENELUX B.V., Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. - OR1, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. - OR2, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-14, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR -30, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-15, Postbus 48 4530 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-18, Postbus 48 4350 AA Terneuzen Netherlands
  • DOW BENELUX B.V. OR-22, Postbus 48 4350 AA Terneuzen Netherlands
  • DOW DEUTSCHLAND ANLAGENGESELLSCHAFT mbH, Buetzflether Sand 2 D-21683 Stade Germany
  • Dow France SAS, 23 Avenue Jules Rimet 93200 La Plaine Saint Denis France
  • DOW ITALIA S.R.L., Via F. Albani 65 20148 Milano Italy
  • Dow Silicones Belgium SPRL, Rue Jules Bordet Zone industrielle C 7180 Seneffe Belgium
  • Dow Silicones Belgium SPRL OR-1, rue Jules Bordet Parc industriel C 7180 Seneffe Belgium
  • Dow Silicones Belgium SPRL OR-2, Rue Jules Bordet Parc industriel C 7180 Seneffe Belgium
  • Dow Silicones Belgium SPRL OR-3, Rue Jules Bordet Zone industrielle C 7180 Seneffe Belgium
  • DOW SVERIGE AB, Box 7038 601 17 Norrköping Sweden
  • Dr. W. Kolb Nederland B.V., Westelijke Randweg 5 4790 AC Klundert Provincie Noord Brabant Netherlands
  • Du Pont de Nemours (Deutschland) GmbH, Hugenottenallee 175 D-63263 Neu-Isenburg Hesse Germany
  • DuPont Specialty Products GmbH & Co. KG, Hugenottenallee 175 63263 Neu-Isenburg Hesse Germany
  • DyStar Colours Distribution GmbH, Am Prime-Parc 12 65479 Raunheim Germany
  • Ecolab APS, Carl Jacobsens Vej 29-37 / Postbox 413 DK-2500 Valby Denmark
  • Ecolab Deutschland GmbH, Ecolab Allee 1 40789 Monheim am Rhein Germany
  • Ecolab Limited, La Vallee House, Upper Dargle Road 0 Bray, Co. Wicklow Ireland
  • Ecolab Production Belgium B.V.B.A., Havenlaan 4 3980 Tessenderlo Belgium
  • Ecolab Production France SAS, 94 Avenue Du General Patton Chalons-En-Champagne 51000 Chalons-En-Champagne France
  • Ecolab Production Italy s.r.l., Via Grandi 9/11 20089 Rozzano Italy
  • EcoMundo, 215 Rue Jean Jacques Rousseau 92130 Issy-les-Moulineaux France
  • Elementis Minerals B.V., Kajuitweg 8 1041AR Amsterdam Netherlands
  • Enzymatic Deinking Technologies, BV, Postbus 36, 2040 A A Zandvoort Netherlands
  • ERM_GmbH_OR14_GUK, Siemenstrasse 9. 63263 Neu Isenburg Hessen Germany
  • Everlight Europe B.V., Rivium Boulevard 224 2909LK Capelle a/d Ijssel Netherlands
  • Evonik Operations GmbH, Rellinghauser Straße 1-11 45128 Essen Germany
  • Evonik Operations GmbH - ME01, Rellinghauser Straße 1-11 45128 Essen Germany
  • Experien Chemical Services (Ireland) Limited, Unit 3D North Point House North Point Business Park, New Mallow Road T23 AT2P Cork Ireland
  • Flint CPS Inks Germany GmbH, Sieglestrasse 25 70464 Stuttgart Germany
  • FUJIFILM Belgium NV, Europark Noord 21-22 9100 Sint-Niklaas Belgium
  • GCP Produits de Construction S.A.S OR5, Za Les Foulletons 39140 Larnaud France
  • Global Life Sciences Solutions Austria GmbH & Co KG, Kremplstraße 5 4061 Pasching Austria
  • Gojo Luxembourg S.à r.l., 1 rue jean piret L-2350 Luxembourg Luxembourg
  • Halliburton Manufacturing and Services Ltd., Columbusstraat 19 7825 VP Emmen Netherlands
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • HH Compliance Ltd., Rubicon Building, CIT Campus Bishopstown none Cork Ireland
  • HH Compliance Ltd., The Rubicon Building, CIT Campus Bishopstown N/A Cork Ireland
  • HH Compliance Ltd., Rubicon Building, CIT Campus Bishopstown Cork Cork Ireland
  • Huntsman (Europe) BV - OR2, Everslaan 45 B-3078 Everberg Belgium
  • Huntsman Advanced Materials (Europe) BV, Everslaan 45 B-3078 Everberg Belgium
  • Huntsman Advanced Materials (Europe) BV OR-USA, Everslaan 45 B-3078 Everberg Belgium
  • HUNTSMAN HOLLAND BV, Merseyweg 10 3197 KG Botlek-Rotterdam Netherlands
  • Huntsman Textile Effects (Germany) GmbH, Rehlinger Str. 1 D-86462 Langweid a.Lech Germany
  • IGM Resins B.V., Gompenstraat 49 5145 RA Waalwijk Netherlands
  • IMCD Benelux OR3, Wilheminaplein 32 3072 DE Rotterdam Netherlands
  • Indorama Netherlands B.V., Markweg 201 3198NB Europoort (Rotterdam) Netherlands
  • INEOS Manufacturing Deutschland GmbH, Alte Strasse 201 50769 Koeln Germany
  • INEOS Styrolution Europe GmbH, Mainzer Landstrasse 50 60325 Frankfurt am Main Germany
  • Infineum Italia, Strada di Scorrimento 2 17047 Vado Ligure (SV) Italy
  • Ingredion Germany GmbH, Gruner Deich 110 20097 Hamburg Germany
  • Innospec Performance Chemicals France SAS (Only Rep), Zone Industrielle de Han Sur Meuse BP19 55300 Saint-Mihiel France
  • Intertek Deutschland GmbH 71, Stangenstrasse 1 70771 Leinfelden- Echterdingen Germany
  • Intertek Deutschland GmbH CJSS, Stangenstr.1 70771 Leinfelden-Echterdingen Baden-Württemberg Germany
  • Intertek Deutschland GmbH CZJP, Stangenstr.1 70771 Leinfelden-Echterdingen Baden-Württemberg Germany
  • Intertek Deutschland GmbH_NAHC, Stangenstr.1 70771 Leinfelden-Echterdingen Germany
  • INTERTEK FRANCE, ZAC Ecoparc II 27400 HEUDEBOUVILLE France
  • ITW Performance Polymers, A Division of ITW Ireland, Bay 150 Shannon Industrial Estate V14 DF82 Shannon Co. Clare Ireland
  • Jiahua Netherlands B.V., Merseyweg 10 - Site 5210 3197 KG Botlek Rotterdam Netherlands
  • Jiahua Netherlands B.V., Merseyweg 10 3197 KG Botlek Rotterdam Netherlands
  • Kao Chemicals Europe, S.L. (10), Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain
  • Kao Chemicals Europe, S.L. (2), Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain
  • Kao Corporation, S.A., Puig dels Tudons, 10 08210 Barbera del Valles Barcelona Spain
  • King Industries International, Science Park 402 1098 XH Amsterdam Amsterdam Netherlands
  • knoell Germany – OR – B10, Konrad-Zuse-Ring 25 68163 Mannheim Germany
  • Knoell NL_OR_070, Agro Business Park 75 6708PV Wageningen Netherlands
  • Kraton Chemical AB OR1, Massvagen 15 P.O. Box 66 SE-820 22 Sandarne Sweden
  • Kromachem GmbH, Fuerstenbergstr. 17 51379 Leverkusen Germany
  • KTR Europe GmbH, Mergenthaleralee 77 65760 Eschborn Germany
  • Kuraray Europe GmbH, Philipp-Reis-Str. 4 65795 Hattersheim Germany
  • Lamberti S.p.A., via Piave 18 21041 Albizzate Varese Italy
  • Lamberti S.p.A. (OR3), via Piave 18 21041 Albizzate Varese Italy
  • Lankem Ireland Limited, 13/15 Rathfarnham Road 6W Dublin Ireland
  • LANXESS Solutions Italy S.r.l., Via Pico della Mirandola, 8 4013 Localita Scalo Latina LT Italy
  • Lubrizol Advanced Materials Europe B.V.B.A, Nijverheidsstraat 30 2260 Westerlo-Oevel Belgium
  • Lubrizol Deutschland GmbH, Max-Planck-Strasse 6 27721 RITTERHUDE Germany
  • Lubrizol Europe Coordination Center BVBA 01, Chaussee De Wavre, 1945 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 02 , Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 30, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol Europe Coordination Center BVBA 33, Chaussee De Wavre 1945 Brussels Belgium
  • Lubrizol France SAS, 25 Quai de France 76100 ROUEN France
  • Lyondell Chemie France S.A.S., Zone Industrielle Portuaire 13270 Fos sur Mer France
  • Lyondell Chemie Nederland B.V., Deltseplein 27E 3013 AA Rotterdam Netherlands
  • LyondellBasell Industries Holdings BV_OR1_Lyondell Chemical Company , Delftseplein 27E 3013 AA Rottterdam Zuid Holland Netherlands
  • Manufacture Française des Pneumatiques Michelin (OR GP), Place des Carmes Déchaux 63040 Clermont Ferrand France
  • Master Builders Solutions Deutschl. GmbH, Dr.-Albert-Frank-Strasse 32 attn. EHSQ Department 83308 Trostberg Germany
  • Merck KGaA, Frankfurter Strasse 250 64293 Darmstadt Germany
  • Merck Life Science A/S, Vandtårnsvej 62A 2860 Søborg Denmark
  • MHM Holding GmbH, Sonnenallee 1 D-85551 Kirchheim Germany
  • Momentive Performance Materials GmbH, Chempark, Building V7 PO 4502311119 51368 Leverkusen NRW Germany
  • Monument Chemical_ORKY, Haven 1972 Ketenislaan 3 9130 Kallo Belgium
  • Münzing Chemie GmbH, Münzingstr. 2 74232 Abstatt Germany
  • MÜNZING CHEMIE GMBH as Only Representative for Ultra Additives LLC dba Munzing, Münzingstr. 2 74232 Abstatt Germany
  • Nalco Europe B.V., Oude Rhijnhofweg 17 2342 BB Oegstgeest Netherlands
  • Nouryon Surface Chemistry AB, Box 47067 40258 Göteborg Sweden
  • Nutrition & Biosciences Netherlands B.V., Willem Einthovenstraat 4 2342 BH Oegstgeest Netherlands
  • Omya GmbH - O1013, Siegburger Str. 229c 50679 Köln Germany Austria
  • Only representative (No publishable name), null
  • OQEMA GmbH, Aachener Str. 258 41061 Moenchengladbach Germany
  • Oxiteno Europe OR2, Ikaroslaan 6 1930 Zaventem Belgium
  • Oxiteno Europe OR5, Ikaroslaan 6 1930 Zaventem Belgium
  • PCC Exol SA, Sienkiewicza 4 56-120 Brzeg Dolny Poland
  • PCC Rokita SA, Sienkiewicza 4 56-120 Brzeg Dolny Poland
  • Penman Consulting bvba 02, Avenue des Arts 10 B-1210 Brussels Belgium
  • Performance Chemicals Handels GmbH, Liebigstr. 2-20 22113 Hamburg Hamburg Germany
  • Performance Fluids B.V, Schiphl Airport Tetra, Transpolispark Siriusdreef 17-27 2132 WT Hoofddorp Netherlands
  • Polywater Europe BV, Zuidhaven 9-11 Unit B7/B8/B9 4761 CR Zevenbergen Netherlands
  • PPG Europe B.V. - OR1, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. - OR3, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • PPG Europe B.V. in its legal capacity as Only Representative of PRC DeSoto International Inc. - OR5, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • Pulcra Chemicals GmbH, Isardamm 79-83 82538 Geretsried Germany
  • Quaker Houghton B.V., Industrieweg 7 1422 AH Uithoorn Netherlands
  • Ravago Chemicals Netherlands BV, Neptunusstraat 15 2132 JA Hoofddorp Netherlands
  • REACH COMPLIANCE SERVICES LIMITED, Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACH COMPLIANCE SERVICES LIMITED, 306 The Capel Building, Mary's Abbey, Dublin 7, Ireland Dublin 7 Dublin Ireland
  • REACH COMPLIANCE SERVICES LIMITED, Suite 1E, Paramount Court, Corrig Road, Sandyford. Dublin 18 Dublin Ireland
  • REACH24H CONSULTING GROUP, Suite 1E, Paramount Court, Corrig Road, Sandyford, Dublin 18, Ireland Dublin 18 Dublin Ireland
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • REACH24H CONSULTING GROUP (acts as OR for SHANDONG ETON NEW MATERIAL CO., LTD), Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACH24H CONSULTING GROUP (Wuhan Youji Industries Co., Ltd), Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 Espoo FI-02600 Espoo Finland
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • REACHLINKED OÜ, Ahtri tn 12 10151 Tallinn Estonia
  • Red Orchid Consulting Oy Ltd, Viherkallionkuja 3 I 59 02710 Espoo Finland
  • REPSOL QUÍMICA, Calle Mendez Alvaro, 44 28045 Madrid Madrid Spain
  • Resonac Europe GmbH (IMP), Daimlerstrasse 19 86368 Gersthofen Germany
  • RHODIA OPERATIONS, 9 rue des Cuirassiers Immeuble Silex 2 Solvay 69003 LYON France
  • RHODIA OPERATIONS - 2, 9 rue des Cuirassiers Immeuble Silex 2 Solvay 69003 Lyon France
  • Richard Baker Harrison (Ireland) Limited , Unit 8 Sandyford Business Centre Blackthorn Road Dublin 18 Sandyford Ireland
  • Roche Diagnostics GmbH, Sandhoferstrasse 116 68305 Mannheim Germany
  • Sasol Germany GmbH, Anckelmannsplatz 1 D-20537 Hamburg Germany
  • SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium
  • Schill + Seilacher GmbH, Schoenaicher Str. 205 71032 Boeblingen Germany
  • Schill+Seilacher "Struktol" GmbH Hamburg, Moorfleeter Straße 28 22113 Hamburg Germany
  • SEDERMA SAS, 29, Rue du Chemin Vert 78612 Le Perray-en-Yvelines France
  • Shell Chemicals Europe B.V., Weena 505 3013 AL Rotterdam Netherlands Netherlands
  • Shell Nederland Chemie B.V., Chemieweg 25 PO BOX 6060, 4782 SJ Moerdijk Netherlands
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • Sigma-Aldrich Ireland Ltd, Vale Road . Arklow Co. Wicklow Ireland
  • Sinopec Europa GmbH, Friedrich Ebert Anlage 49, MesseTurm 60308 Frankfurt am Main Germany
  • SNF SA, ZAC de Milieux 42163 Andrézieux France
  • Specialty Electronic Materials Belgium SRL OR-1, Boulevard d’Angleterre 2 1420 Braine-l’Alleud Belgium
  • Specialty Electronic Materials Netherlands BV OR-1, Baanhoekweg 22 3313 LA Dordrecht Netherlands
  • Specialty Electronic Materials Netherlands BV OR-3, Baanhoekweg 22 3313 LA Dordrecht Netherlands
  • Specialty Electronic Materials Netherlands BV OR-7, Baanhoekweg 22 3313 LA Dordrecht Netherlands
  • Stahl Europe B.V., Sluisweg 10 5145PE Waalwijk Noord Brabant Netherlands
  • STEPAN DEUTSCHLAND Gmbh, Rodenkirchener Strasse 400 D-50389 WESSELING Germany
  • STEPAN EUROPE SA, Chemin JONGKIND 38340 VOREPPE France
  • STEPAN POLSKA, Urazka Street PL 56-120 Brzeg Dolny Poland
  • StonCor Europe, Rue du Travail, 9 1400 Nivelles Belgium
  • Sun Chemical B.V., Leeuwenveldseweg 3-t 1382 LV Weesp Netherlands
  • Syngenta Hellas Single Member S.A.C.I., Anthousas Avenue 153 49 Anthousa-Attiki Greece
  • Syngenta Hellas Single Member S.A.C.I., Anthousas Avenue 153 49 Anthousa-Attiki Greece
  • Syngenta Hellas Single Member S.A.C.I., Anthousas Avenue 153 49 Anthousa - Attiki Greece
  • Syngenta Production France SAS, 55, rue du Fond du Val 27600 Saint-Pierre-La-Garenne France
  • Tecnofluid Srl, Via Mons. Colombo 34 21053 Castellanza VA Italy
  • TFL ITALIA SpA, Via dei Campacci 11 20010 Buscate MI Italy
  • Toyota Tsusho Europe S.A., Belgicastraat 13 1930 Zaventem Belgium
  • TÜV SÜD Iberia S.A.U., Ronda Can Fatjó, 13 Parc Tecnològic del Vallès 08290 Cerdanyola del Vallès Spain
  • TÜV SÜD Iberia S.A.U. (023), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • TÜV SÜD Iberia S.A.U. (065), Ronda Can Fatjó 13 08290 Cerdanyola del Vallès Barcelona Spain
  • TÜV SÜD Industrie Service GmbH (17), Westendstrasse 199 80686 Munich Germany
  • TÜV SÜD Industrie Service GmbH (60), Westendstrasse 199 80686 Munich Germany
  • UBE Corporation Europe, S.A.U. (OR1), Polígono Industrial El Serrallo s/n 12100 Castellón CASTELLON Spain
  • Vantage Specialty Chemicals, 3 rue Jules Guesde 91130 RIS ORANGIS France
  • Veolia Water Technologies & Solutions Belgium BVBA, Toekomstlaan 54 2200 Herentals Belgium
  • Veolia WTS France, Immeuble L'Aquarène 1 place Montgolfier 94417 SAINT-MAURICE CEDEX France
  • Vink+Co GmbH Handelsgesellschaft und Co.KG, Eichenhöhe 24 21255 Kakenstorf Germany
  • W. L. Gore & Associates GmbH, Hermann-Oberth-Strasse 22 85640 Putzbrunn Germany
  • Wacker Chemie AG, Hanns-Seidel-Platz 4 81737 Muenchen Germany
  • Wacker Chemie AG (OR_WCC), Johannes-Hess-Strasse 24 84489 Burghausen Germany
  • Westlake Epoxy B.V., Seattleweg 17, building 4 3195 ND Pernis-Rotterdam Netherlands
  • Westlake Epoxy B.V. OR, Seattleweg 17, Building 4 3195 ND Pernis-Rotterdam Netherlands
  • YOU Solutions Germany GmbH - REACH (part of Arxada), Freundallee 9 a 30173 Hannover Germany
  • [Confidential], [Confidential]
  • Arcerion GmbH, Gabrielenstr. 15 80636 München Germany
  • Archroma France, SAS, Rue du Flottage 60350 Trosly-Breuil France
  • Archroma Italy, S.r.l., Via Manzoni 37 20030 Palazzolo Milanese Italy
  • Archroma UK, Ltd, 1 Bartholomew Lane EC2N 2AX London United Kingdom
  • Chemservice S.A - (G2B9), 13, Fausermillen 6689 Mertert Luxembourg
  • Chemservice S.A - (G5B1), 13, Fausermillen 6689 Mertert Luxembourg
  • Chemtura Europe Limited (T809), Kennet House 4 Langley Quay SL3 6EH Langley, Slough United Kingdom
  • Corteva Agriscience UK Limited, CPC2 Capital Park, Fulbourn Cambridge CB21 5XE Cambridgeshire United Kingdom
  • DSP S.A.S., 22, rue Brunel 75017 Paris France
  • Du Pont (U.K.) Industrial Limited, 60 Clooney Rd Maydown Works BT47 6TH Londonderry United Kingdom (Northern Ireland)
  • Du Pont (U.K.) Limited, London Road 4th Floor, Kings Court SG1 2NG Stevenage Hertfordshire United Kingdom
  • DuPont Nutrition Norge AS, Industriveien 33 N-1337 Sandvika Norway
  • Henkel AG & Co. KGaA, Henkelstrasse 67 40191 Duesseldorf North-Rhine Westfalia Germany
  • Henkel AG & Co. KGaA - Only Representative NSC Japan, Henkelstrasse 67 40589 Duesseldorf Germany
  • Henkel Balti Operations OÜ, Sopruse pst. 145 13417 Tallinn Estonia
  • Henkel Belgium Operations N.V., Havenlaan 16 1080 Brussels Belgium
  • Henkel Central Eastern Europe Operations GmbH, Erdbergstr. 29 1030 Wien Austria
  • Henkel Electronic Materials (Belgium) N.V., Nijverheidsstraat 7 2260 Westerlo Belgium
  • Henkel Hellas SA, 23, Kyprou Street 18346 Athen-Moschato Greece
  • Henkel Iberica S.A., Calle Bilbao 72-84 08005 Barcelona Spain
  • Henkel Ireland Operations and Research Limited, Tallaght Business Park Whitestown 24 Dublin Ireland
  • Henkel Italia Operations S.r.L., Via Amoretti 78 20157 Mailand Italy
  • Henkel Ltd., Wood Lane End HP2 4RQ Hemel Hempstead, United Kingdom
  • Henkel Magyarország Operations Kft., David Ferenc utca 6 1113 Budapest Hungary
  • Henkel Norden AB, Gustavslundsvägen 151 A P.O Box 15022 167 15 Bromma Sweden
  • Henkel Polska Operations SP.z.o.o., Domaniewska 41 02-672 Warszawa Poland
  • Henkel Technologies France SAS, 161 Rue De Silly 92100 Boulogne-Billancourt France
  • Hexion UK Limited, Sully Moors Road CF64 5YU Sully South Glamorgan United Kingdom
  • Huntsman (Europe) BV - OR1, Everslaan 45 B-3078 Everberg Belgium
  • IFF OR NL2, International Flavors & Fragrances I.F.F. (Nederland) B.V. Liebergerweg 72-98 1221JT Hilversum Noord-Holland Netherlands
  • INFO_CARE_USP, Tiberiusweg 9 3453 KZ De Meern Netherlands
  • Kuraray Europe GmbH (OR1), Philipp-Reis-Str. 4 65795 Hattersheim Germany
  • LANXESS Manufacturing Netherlands B.V., Ankerweg 18 1041 AT Amsterdam (2079) 08 Netherlands
  • Lubrizol Limited 26, The Knowle Nether Lane DE56 4AN Derby United Kingdom
  • LUKOIL Neftohim Burgas AD (KNH), Western Industrial Zone 8104 Bourgas Bulgaria
  • MC (Netherlands) 1 B.V. OR_CH, Willem Einthovenstraat 4 2342BH Oegstgeest Netherlands
  • momaja s.r.o., Karolinska 650/1 186-00 Prague Czech Republic
  • NetSun EU B.V., Blaak 40, Fifth Floor, 3011 TA 3011 TA Rotterdam Netherlands
  • NGF EUROPE Limited, Lea Green Road WA9 4PR St. Helens Merseyside United Kingdom
  • Only representative (No publishable name), null
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • REACH24H CONSULTING GROUP, Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • SAFC Biosciences Limited, Smeaton Road, West Potway SP10 3LF Andover United Kingdom
  • SC31-Ele Corporation, Długosza 67 43-188 Orzesze Poland
  • Sigma-Aldrich Company Limited, The Old Brickyard, New Road SP8 4XT Gillingham United Kingdom
  • SLM Solutions Group AG, Estlandring 4 23560 Lübeck Germany
  • Specialty Electronic Materials Netherlands BV, Baanhoekweg 22 3313 LA Dordrecht Netherlands
  • Synovelle Limited, Synovelle Wessex house, Upper market street SO50 9FD Eastleigh Hampshire United Kingdom
  • The Acta Group EU BVBA (BE23), Place du Luxembourg 2 1050 Brussels Belgium
  • The Acta Group EU BVBA (BE36), Place du Luxembourg 2 1050 Brussels Belgium
  • TOYOTA TSUSHO UK Ltd, Pond End, Willow Farm Business Park DE74 2UB Castle Donnington Derbyshire United Kingdom
  • TÜV SÜD Industrie Service GmbH (11), Westendstr. 199 80686 Munich Germany
  • UEBV OR 03, Weena 455 3013 AL Rotterdam Netherlands
  • Unilever Nederlands Services BV 04, Weena 455 3013 AL Rotterdam Netherlands

Substance names and other identifiers

1,2-Epoxypropane
CMD - Carcinogens and Mutagens Directive, Annex III - OELVs
Methyloxirane
EC Inventory, REACH pre-registration
Methyloxirane
REACH pre-registration, Cosmetic Products Regulation, Annex II - Prohibited Substances
Methyloxirane (Propylene oxide)
Candidate list
Oxirane, methyl-
Other
PROPYLENE OXIDE
Other, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616
propylene oxide 1,2-epoxypropane methyloxirane
C&L Inventory
propylene oxide; 1,2-epoxypropane; methyloxirane
FCM Active and Intelligent Materials - CMRs not allowed for use, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work
1,2-epoksypropan metylooksiran tlenek propylenu (pl)
C&L Inventory
1,2-προπυλενοξείδιο 1,2-εποξυπροπάνιο μεθυλοξιράνιο (el)
C&L Inventory
ossido di propilene 1,2-epossipropano metilossirano (it)
C&L Inventory
oxyde de propylène 1,2-époxypropane méthyloxiranne (fr)
C&L Inventory
propilen oksid 1,2-epoksipropan metil oksiran (sl)
C&L Inventory
propilen oxid 1,2-epoxipropan metiloxiran (ro)
C&L Inventory
propileno oksidas 1,2-epoksipropanas metiloksiranas (lt)
C&L Inventory
propilén-oxid 1,2-epoxipropán metiloxirán (hu)
C&L Inventory
propilēnoksīds 1,2-epoksipropāns metiloksirāns (lv)
C&L Inventory
Propyleenioksidi 1,2-Epoksipropaani Metyylioksiraani (fi)
C&L Inventory
propyleenoxide 1,2-epoxypropaan methyloxiraan (nl)
C&L Inventory
propylenoksid 1,2-epoksypropan metyloksiran (no)
C&L Inventory
propylenoxid 1,2-epoxipropan metyloxiran (sv)
C&L Inventory
propylenoxid 1,2-epoxypropan methyloxiran (cs)
C&L Inventory
propylenoxid 1,2-epoxypropan methyloxiran (da)
C&L Inventory
Propylenoxid 1,2-Epoxypropan Methyloxiran (de)
C&L Inventory
propylénoxid 1,2-epoxypropán metyloxirán (sk)
C&L Inventory
Propüleenoksiid 1,2-epoksüpropaan metüüloksiraan (et)
C&L Inventory
óxido de propileno 1,2-epoxipropano metiloxirano (es)
C&L Inventory
óxido de propileno 1,2-epoxipropano metiloxirano (pt)
C&L Inventory
пропилен оксид 1,2-епоксипропан мeтилоксиран (bg)
C&L Inventory
(2R)-2-methyloxirane
C&L Inventory
(±)-Methyloxirane, Methyloxirane, 1,2-Epoxypropane, 1,2-Propylene oxide, (±)-Propylene oxide, Propylene oxide,
Registration dossier
1,2-Epoxyethane
Registration dossier
1,2-epoxypropane
C&L Inventory, Registration dossier
1,2-Epoxypropane
C&L Inventory, Registration dossier
1,2-Propylene oxide
Registration dossier
2- methyloxirane
C&L Inventory
2-Methyloxirane
C&L Inventory, Registration dossier, Other
2-methyloxirane
C&L Inventory, Registration dossier, Other
epoxypropane
C&L Inventory, Registration dossier
methylooxirane
C&L Inventory
Methyloxirane
C&L Inventory, Registration dossier
Methyloxirane
C&L Inventory, Registration dossier
Methyloxirane, 1,2-Epoxypropane, 1,2-Propylene oxide, (±)-Propylene oxide, Propylene oxide
Registration dossier
methyloxirane, propylene oxide
Registration dossier
Methyloxirane; Propylene Oxide
Registration dossier
oxirane
C&L Inventory, Registration dossier
Oxirane, methyl-
Registration dossier
Oxypropylene , Propylene oxide
Registration dossier
PO
Registration dossier
propene oxide
Registration dossier
Propylene Oxide
C&L Inventory, Registration dossier
Propylene Oxide
C&L Inventory, Registration dossier
Propylene Oxide (methyloxirane)
Registration dossier
propylene oxide monomer
Registration dossier
Propylene oxide, Methyl oxirane
Registration dossier
propylene oxide, methyloxirane
Registration dossier
Propylene oxide; 1,2-epoxypropane, methyl Oxirane, PO
Registration dossier
propylene oxide; 1,2-epoxypropane; methyloxirane
C&L Inventory
propylene oxide|1,2-epoxypropane|methyloxirane
C&L Inventory
Propyleneoxide
Registration dossier
Propylenoxid
C&L Inventory, Registration dossier
Propylenoxid
C&L Inventory, Registration dossier
1,2-Ep-oxypropane
Registration dossier
1,2-Epoxypropane
Registration dossier
1,2-Propylene oxide
Registration dossier
2,3-Epoxypropane
Registration dossier
2-methyloxirane
Registration dossier
CHINT: PO
Registration dossier
CIM-67
Registration dossier
different trade names
Registration dossier
DOW Propylene Oxide
Registration dossier
Epoxypropane
Registration dossier
methyl oxirane
Registration dossier
Methyloxacyclopropane
Registration dossier
Methyloxirane
Registration dossier
not known
Registration dossier
Oxirane, methyl-
Registration dossier
Oxirane, methyl- (9CI)
Registration dossier
Oxypropylene
Registration dossier
Oxypropylene (6CI)
Registration dossier
Phase noch nicht bestimmt
Registration dossier
Pluronic 174R
Registration dossier
Pluronic F127
Registration dossier
PO
Registration dossier
PPG
Registration dossier
Propane, 1,2-epoxy-
Registration dossier
Propane, 1,2-epoxy- (7CI)
Registration dossier
Propene oxide
Registration dossier
Propylene Epoxide
Registration dossier
PROPYLENE OXIDE
Registration dossier
Propylene oxide (8CI)
Registration dossier
Propylene Oxide (PO)
Registration dossier
propylene oxide,
Registration dossier
Propylenoxid
Registration dossier
propylenu tlenek
Registration dossier
Resin 8020 A
Registration dossier
Resin 8020 B
Registration dossier
Resin 8040 A
Registration dossier
Resin 8052 A
Registration dossier
Resin 8060 A
Registration dossier
Resin 8095 A
Registration dossier
Resin 8095 A-LP
Registration dossier
Resin SG 95 A
Registration dossier
Resin SG 95 A-LP
Registration dossier
Resin SG 95 NA
Registration dossier
Propylene oxide
Candidate list
16033-71-9
CAS number
Other
603-055-00-4
Index number
C&L Inventory
75-56-9
CAS number
EC Inventory, C&L Inventory, Candidate list, Registration dossier, REACH pre-registration, Other, FCM Active and Intelligent Materials - CMRs not allowed for use, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, Inland Transport of Dangerous Goods Directive, Annex III - ADN, Inland Transport of Dangerous Goods Directive, Annex I - ADR, Inland Transport of Dangerous Goods Directive, Annex II - RID, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Regulation - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Medical Devices Regulation - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, CMD - Carcinogens and Mutagens Directive, Annex III - OELVs, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 9 studies submitted
  • 5 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [5]
C Form
Other (100%) [4]
C Odour
Other (100%) [5]
C Substance type
Organic (100%) [5]

Type of Study provided
Studies with data
Key study 5 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 5 studies submitted
  • 1 study processed
R Melting / freezing point
-112 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
-112.15 °C

Boiling point

Study results
  • 5 studies submitted
  • 5 studies processed
R Boiling point
34.23 - 35 °C @ 101.3 - 104.13 kPa [5]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
34.85 °C

Density

Study results
  • 5 studies submitted
  • 5 studies processed
R Relative density
0.83 - 0.83 @ 20 °C [5]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
0.83

Vapour pressure

Study results
  • 5 studies submitted
  • 5 studies processed
R Vapour pressure
71.727 - 74 kPa @ 25 °C [5]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
74 kPa @ 25 °C

Partition coefficient

Study results
  • 2 studies submitted
  • 1 study processed
R Log Pow
1 @ 20 °C and pH 6.8 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
0.055 @ 20 °C

Water solubility

Study results
  • 5 studies submitted
  • 4 studies processed
R Water solubility (mass/vol.)
395 - 405 g/L @ 20 °C and pH 7 [4]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
425 mg/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 5 studies submitted
  • 1 study processed
R Surface tension
71.5 mN/m @ 1.06 g/L and 21 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
R Summaries
  • 1 summary submitted
  • 1 summary processed
Surface tension at 20 °C
71.5 mN/m @ 1 060 mg/L

Flash point

Study results
  • 5 studies submitted
  • 5 studies processed
R Flash point
-38 - -37.222 °C @ 100.75 kPa [5]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
-38.15 °C

Auto flammability

Study results
  • 5 studies submitted
  • 5 studies processed
R Autoflammability / self-ignition
400 - 449 °C @ 100.49 - 101.83 kPa [5]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Extremely flammable (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 4
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 2 studies submitted
  • 1 study processed
R kinematic viscosity (in mm²/s)
0.374 - 0.447 [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Static viscosity at 20 °C
0.374 mm²/s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
32 days

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 6 studies submitted
  • 4 studies processed
C Interpretation of results
Readily biodegradable (100%) [4]

Type of Study provided
Studies with data
Key study 5
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 52 µg/L (1)
Intermittent releases (freshwater) 520 µg/L (1)
Marine water 5.2 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 10 mg/L (1)
Sediment (freshwater) 245 µg/kg sediment dw (1)
Sediment (marine water) 24.5 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 18.6 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 7 studies submitted
  • 5 studies processed
P/RResults
LC50 (4 days) 52 - 141 mg/L [5]

Type of Study provided
Studies with data
Key study 5
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 5 studies submitted
  • 5 studies processed
P/RResults
EC50 (48 h) 350 mg/L [5]
EC50 (24 h) 650 mg/L [5]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic algae and cyanobacteria

Study results
  • 5 studies submitted
  • 5 studies processed
P/RResults
EC50 (4 days) 240 mg/L [5]
NOEC (4 days) 100 mg/L [4]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
240 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for microorganisms
100 mg/L

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: (DNEL) 2.4 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 170 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: (No hazard identified) -
Local Effects
Long-term: (DNEL) 600 µg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 170 mg/m³ -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 5 studies submitted
  • 5 studies processed
P/RResults
LD50 382 - 587 mg/kg bw (rat) [5]

Type of Study provided
oral
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 5 studies submitted
  • 1 study processed
P/RResults
LC50 (4 h) 4 197 ppm (rat) [1]

inhalation
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 5 studies submitted
  • 5 studies processed
P/RResults
LD50 950 - 1 250 mg/kg bw (rabbit) [4]
LD50 1.5 mL/kg bw (rabbit) [1]

dermal
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Study data: eye
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 4
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 5 studies submitted
  • 4 studies processed
P/RResults
LOEL (rat): 300 mg/kg bw/day [4]

Type of Study provided
Study data: oral
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: inhalation
  • 14 studies submitted
  • 7 studies processed
P/RResults
NOAEC (rat): 30 ppm [1]
LOAEC (rat): 200 ppm [1]
LOAEC (mouse): 200 ppm [1]
LOEC (rat): 362 mg/m³ air [4]

Study data: inhalation
Studies with data
Key study 7
Supporting study 7
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 7
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 9
Supporting study 4 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 7
Supporting study 2 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 6
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant