Registration Dossier
Registration Dossier
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EC number: 269-822-7 | CAS number: 68334-30-5 A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C20 and boiling in the range of approximately 163°C to 357°C (325°F to 675°F).
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
A few case studies reported gastrointestinal, hematological, renal, neurological, dermal effects in humans after inhalation and/or dermal exposures to Diesel Fuel.
As observed in animal studies, repeated dose toxicity of Diesel Fuel is associated with development of skin lesions (dermatitis, inflammation, histopathological changes) after dermal exposures to this substance. Dermal exposures were also associated with renal toxicity and hepatotoxicity in experimental animals.
Inhalation of Diesel Fuel vapour or mist/aerosols may result in depression of CNS and respiratory system toxicity.
The following systemic toxicity values were observed in animal studies:
Short-term Toxicity (up to 28 days/4 weeks exposure):
· LOAEL (subacute, inhalation, mice) =65 mg/m3 (mild transient neurological effects)
Subchronic Exposure (up to 90 days/ 13 weeks):
· LOAEL (subchronic, dermal, mice) =250 mg/kg bw/day –skin lesions, hepatotoxicity.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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