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EC number: 269-822-7 | CAS number: 68334-30-5 A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C20 and boiling in the range of approximately 163°C to 357°C (325°F to 675°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referred in a recognized source of peer reviewed scientific data on chemicals
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological Profile for Fuel Oils
- Author:
- ATSDR
- Year:
- 1 995
- Bibliographic source:
- Agency for Toxic Substances and Disease Registry, June 1995
Materials and methods
- Objective of study:
- other: Science peer review report
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Science peer review report
- Principles of method if other than guideline:
- Science peer review report
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hydrocarbons in the aromatic EC<9 fraction
- IUPAC Name:
- Hydrocarbons in the aromatic EC<9 fraction
- Reference substance name:
- Hydrocarbons in the aromatic EC>9 –EC16 fraction:
- IUPAC Name:
- Hydrocarbons in the aromatic EC>9 –EC16 fraction:
- Reference substance name:
- Hydrocarbons in the aliphatic EC5 –EC8 fraction:
- IUPAC Name:
- Hydrocarbons in the aliphatic EC5 –EC8 fraction:
- Reference substance name:
- Hydrocarbons in the aliphatic EC>8 –EC16 fraction:
- IUPAC Name:
- Hydrocarbons in the aliphatic EC>8 –EC16 fraction:
- Details on test material:
- Data on individual components (fractions) of Diesel Fuel
Constituent 1
Constituent 2
Constituent 3
Constituent 4
Results and discussion
Any other information on results incl. tables
Data on individual components (fractions):
Hydrocarbons in the aromatic EC<9 fraction:
readily absorbed following inhalation or oral exposure, based on studies with humans and animals;
absorbed by the skin to a lesser extent, especially with exposure to vapors;
widely distributed throughout tissues and organs following absorption;
metabolized (via oxidative metabolic pathways involving cytochrome P-450) to more water-soluble metabolites that are excreted predominately in urine;
eliminated by exhalation of unchanged parent compound and urine and fecal excretion.
Hydrocarbons in the aromatic EC>9 –EC16 fraction:
may be absorbed following inhalation, oral, or dermal exposure, based on studies of humans and animals;
widely distributed following absorption;
metabolism involves aromatic ring oxidation;
urinary excretion of metabolites is the primary route of elimination.
Hydrocarbons in the aliphatic EC5 –EC8 fraction:
may be readily absorbed in the lungs, as indicated by studies of humans and animals;
absorption by the oral and dermal route is not well characterized;
widely distributed to tissues and organs with preferential partitioning into fatty tissues and well perfused tissues;
oxidatively metabolized predominately in the liver;
excreted in urine as metabolised form; exhaled unchanged.
Hydrocarbons in the aliphatic EC>8 –EC16 fraction:
absorption of aliphatic hydrocarbons (n-alkanes, isoparaffins, and naphthenes) is inversely related to molecular weight, ranging from complete absorption at the lower end of the molecular weight range to essentially no absorption for aliphatic hydrocarbons with >32 carbons;
widely distributed to tissues with preferential distribution and accumulation occurring in fatty tissues;
slowly eliminated.Applicant's summary and conclusion
- Conclusions:
- The data on toxicokinetics of Diesel Fuel components/fractions suggest that short-chain hydrocarbons can be readily absorbed whereas long-chain aliphatic hydrocarbons have only limited absorption potential after inhalation, oral and ingestion exposure routes.
Depending on its chemical structure, absorbed hydrocarbons are widely distributed throughout tissues and organs, metabolised and excreted with urine and faeces, or exhaled unchanged.
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