4-amino-N-(2-ethylhexyl)benzenesulphonamide

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1976-03-09 to 1977-06-07

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Inhalation hazard test with acceptable restrictions (limited documentation)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1977

Report date:

1977

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

other: according to H.F. Smyth and C.P. Carpenter, J. Ind. Hyg. Toxicol. 28, 1944

Test guideline 2

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

yes

Remarks:

limited documentation

GLP compliance:

no

Test type:

other: inhalation hazard test

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

4-amino-N-(2-ethylhexyl)benzenesulphonamide

EC Number:

258-799-9

EC Name:

4-amino-N-(2-ethylhexyl)benzenesulphonamide

Cas Number:

53817-09-7

Molecular formula:

C14H24N2O2S

IUPAC Name:

4-amino-N-(2-ethylhexyl)benzene-1-sulfonamide

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source:
- Age at study initiation:
- Weight at study initiation: mean of three males 583 g; mean of three females 492 g
- Diet: The animals were offered a standardized animal laboratory diet Altromin R 1324 (Altromin GmbH, Lage, Germany)

IN-LIFE DATES: From: 1976-03-09 To: 1976-03-17

Administration / exposure

Route of administration:

inhalation: dust

Type of inhalation exposure:

whole body

Vehicle:

other: air was cleansed via passage through a washing flask

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: exciccator, washing flask
- Source and rate of air: at room temperature air was saturated with test item via passage through a 5 cm thick layer of the test item at a rate of 200 L air per h.
- Method of conditioning air: see above
- System of generating particulates: substance with slight dustiness
- Temperature, humidity, pressure in air chamber: room temperature, ambient conditions

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

Mean concentration 1.16 mg/L.
No analytical determination of the atmosphere concentrations was performed. The nominal concentrations were calculated as quotient of the of the amount of test substance weight loss during exposure and the amount of air used during the exposure.

No. of animals per sex per dose:

3

Control animals:

no

Details on study design:

- Duration of observation period following administration: 8 days
- Frequency of observations and weighing: on days 0, 1, 2, 7, and 8
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, necropsy

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 1.16 mg/L air (nominal)

Based on:

test mat.

Exp. duration:

8 h

Mortality:

None

Clinical signs:

other: None reported

Body weight:

Normal body weight development reported

Gross pathology:

Nothing abnormal detected