Butan-2-one O,O',O''-(vinylsilylidyne)trioxime

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1997

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

Studies conducted by the Japanese Ministry of the Environment based on based on OECD-GLP standard and OECD test guidelines.

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Deviations:

not specified

Remarks:

(no details on method are given)

GLP compliance:

yes

Analytical monitoring:

yes

Details on sampling:

Measurement frequency: start of exposure, end of exposure

Test organisms (species):

Daphnia magna

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Test temperature:

20 ± 1 ºC

Nominal and measured concentrations:

Nominal concentrations: 0 (control), 52.9, 95.3, 171, 309, 556 and 1000 mg/L.
Measured concentrations: not available.

Details on test conditions:

TEST SYSTEM
- Material, size, headspace, fill volume: 200 ml per vessel
- No. of organisms per vessel: 20
- No. of vessels per concentration (replicates): 5
- No. of vessels per control (replicates): 4

OTHER TEST CONDITIONS
- Photoperiod: 16 hours light - 8 hours dark
- Light intensity: room light

TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.8

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

201 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: 95 % CL: 171 - 309 mg/L

Validity criteria fulfilled:

not specified

Conclusions:

The 48h-EC50 of 2-butanone oxime in Daphnids was determined to be 201 mg/L.

Executive summary:

A Daphnia Acute Immobilisation Test was performed by the Japanese Ministry of Environment according to OECD TG 202. 20 daphnias were exposed to 2 -butanone oxime at nominal concentrations of 0 (control), 52.9, 95.3, 171, 309, 556 and 1000 mg/L. (4 replicates) under static conditions. The 48h-EC50 of test substance 2 -butanone oxime in Daphnids was determined to be 201 mg/L.

Reference 2

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

REPORTING FORMAT FOR THE ANALOGUE APPROACH
Butan-2-one O,O',O''-(vinylsilanetriyl)oxime undergoes rapid hydrolysis in aqueous to butanone oxime and the corresponding silanol. Silanetriol undergo continuous condensation reactions to produce higher molecular weight siloxanes which are considered biologically unavailable. Therefore, the observed toxicity is likely due to butanone oxime and their values are comparable.
See attached the reportinf format.

Reason / purpose for cross-reference:

read-across source

Key result

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

214.08 mg/L

Nominal / measured:

estimated

Conc. based on:

other: (analogue substance)

Basis for effect:

mobility

Remarks on result:

other: (Based on read-across approach from an analogue)

Details on results:

Based on the experimental results obtained with the analogue substance butanone oxime (48h EC50 =201 mg/L ), the read-across approach is applied and the 48h EC50 for butan-2-one O,O',O''-(vinylsilanetriyl)oxime was calculated to be 214.08 mg/L.

Validity criteria fulfilled:

not applicable

Conclusions:

Based on the read-across approach from experimental results on analogue butanone oxime, 48 -EC50 for butan-2-one O,O',O''-(vinylsilanetriyl)oxime in Daphnids was determined to be 241.08 mg/L.

Executive summary:

A Daphnia Acute Immobilisation Test was performed on analogue substance butanone oxime by the Ministry of Environment of Japan according to OECD TG 202. The 48h-EC50 was determined to be 201 mg/L. Based on these results, the read-across was applied and the 48 -EC50 for butan-2-one O,O',O''-(vinylsilanetriyl)oxime in Daphnids was determined to be 241.08 mg/L.

Description of key information

Key study: Read-across from experimental data on analogue butanone oxime: The 48h-EC50 of butan-2-one O,O',O''-(vinylsilanetriyl)oxime in Daphnids was determined to be 241.08 mg/L.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

241.08 mg/L

Additional information

Key study: Read-across approach from analogue butanone oxime:

Based on the read-across approach from experimental results on analogue butanone oxime (test method OECD 202, 48h-LC50 Daphnids = 201 mg/L), the 48h-EC50 of butan-2-one O,O',O''-(vinylsilanetriyl)oxime in Daphnids was determined to be 241.08 mg/L.