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Diss Factsheets
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EC number: 248-502-0 | CAS number: 27503-81-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Sep. 20, 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Qualifier:
- according to guideline
- Guideline:
- ISO 8192 (Water quality - Test for inhibition of oxygen consumption by activated sludge for carbonaceous and ammonium oxidation)
- Qualifier:
- according to guideline
- Guideline:
- other: ETAD 103
- GLP compliance:
- no
- Analytical monitoring:
- no
- Details on sampling:
- no data
- Vehicle:
- no
- Details on test solutions:
- Inoculum: 3 L laboratory scale unit (OECD)
- Test organisms (species):
- activated sludge
- Details on inoculum:
- Determination of dry weight: 1.00 g
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Hardness:
- no data
- Test temperature:
- 20.6 - 22.1 °C
- pH:
- 7.9 - 8.6
- Dissolved oxygen:
- no data
- Salinity:
- no data
- Nominal and measured concentrations:
- nominal: 100, 1000 and 10000 mg/L
- Details on test conditions:
- Nutrient medium: according to ISO 8192-1986, chapter 4.2
- Reference substance (positive control):
- yes
- Remarks:
- 3,5-Dichlorophenol
- Key result
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Key result
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 10 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Details on results:
- All the respiration rate inhibitions with test substance were 0 % at the concentrations of 100, 1000 and 10000 mg/L.
- Results with reference substance (positive control):
- Test concentration Respiration rate inhibition
1 mg/L 6 %
20 mg/L 62 % - Validity criteria fulfilled:
- yes
- Conclusions:
- No inhibition effects were observed up to the maximum tested concentration of 10000 mg/L. Therefore, the NOEC was determined to be 10000 mg/L and the EC50 to be >10000 mg/L (nominal conc.), respectively.
- Executive summary:
The test was performed to determine the respiration rate inhibition on microorganisms of the test substance. This test was performed according to the ISO standard. Three concentrations of 100, 1000 and 10000 mg/L were set at the test exposure of 3 hours. The result showed all the respiration rate inhibitions were 0 % at the three test concentrations. In conclusion, the EC50 was >10000 mg/L (nominal conc.).
Reference
Description of key information
The toxicity to microorganims was determined in an ISO standard study. No inhibition effects were observed up to the maximum tested concentration of 10000 mg/L. Therefore, the NOEC was determined to be 10000 mg/L and the EC50 to be >10000 mg/L (nominal conc.), respectively.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 10 000 mg/L
Additional information
The available microorganism test was performed according to the ISO standard. Three concentrations of 100, 1000 and 10000 mg/L were set at the test exposure of 3 hours. The result showed all the respiration rate inhibitions were 0 % at the three test concentrations.
the NOEC was determined to be 10000 mg/L and the EC50 to be >10000 mg/L (nominal conc.), respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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