2-phenyl-1H-benzimidazole-5-sulphonic acid

Endpoint summary

Description of key information

The substances prooved to be not toxic for aquatic organisms.

Short-term toxicity to fish

The short term toxicity to fish was determined in an OECD guideline study. The LC0 value was determined to be ≥100 mg/L.

Long-term toxicity to fish

The long-term toxicity to fish was calculated with a valid QSAR model (ECOSAR v2.0 Fish Chronic Value Pyrroles-Diazoles; see QMRF & QPRF). The ChV (geometric mean of NOEC and LOEC) was determined to be 65.22 mg/L.

Short-term toxicity to aquatic invertebrates

The short-term toxicity to aquatic invertebrates was determined in a long-term toxicity study (OECD 211). The EC50 at 48 h in the long-term toxicity study was determined to be ≥100 mg/L.

Long-term toxicity to aquatic invertebrates

The long-term toxicity of the test item was determined in an OECD guideline study. The EC10 based on reproduction, survival and mortality were determined to be >100 mg/L. The NOEC was determiend to be ≥100 mg/L.

 Toxicity to aquatic algae and cyanobacteria

The toxicity to aquatic algae and cyanobacteria was determined in an OECD guideline study. The EC50 (growth rate) was determined to be >100 mg/L. The NOEC was determined to be ≥100 mg/L.

 Toxicity to microorganisms

The toxicity to microorganims was determined in an ISO standard study.No inhibition effects were observed up to the maximum tested concentration of 10000 mg/L. Therefore, the NOEC was determined to be 10000 mg/L and the EC50 to be >10000 mg/L (nominal conc.), respectively.

Additional information

Study reports are available for tests with alga, fish, invertebrates and micro-organism. In none of the tests effects were observed within and even above the water solubility.

 

The results are summarized as follows:

Alga growth inhibition test: Based on the key study result according to OECD TG 201 under GLP compliance, the results were as follows: 72-h EC50 (based on growth rate) >100 mg/L; 72-h LOEC (based on growth rate) >100 mg/L; 72-h NOEC (based on growth rate) ≥100 mg/L.

 

Fish acute toxicity test: Based on the key study result according to OECD TG 203 under GLP compliance, the LC0 (96 h) was ≥10000 mg/L.

 

Daphnia acute toxicity test: A 48-h EC50 was determined in a long-term toxicity test with Daphnia magna (OECD 211). It was determined that the EC50 (48h) is >100 mg/L.

 

Daphnia chronic toxicity test: The EC10 based on reproduction, survival and mobility were determined to be >100 mg/L. The NOEC was determined to be ≥100 mg/L.

 

Microorganism respiration inhibition test:

The toxicity to microorganims was determined in an ISO standard study.No inhibition effects were observed up to the maximum tested concentration of 10000 mg/L. Therefore, the NOEC was determined to be 10000 mg/L and the EC50 to be >10000 mg/L (nominal conc.), respectively.

 

Furthermore a valid QSAR shows that no relevant long-term toxicity to fish is expected neither (ChV= 65.22 mg/L).