Registration Dossier

Diss Factsheets

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16 Apr 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
GLP compliance:
no
Type of method:
flask method
Water solubility:
> 330 g/L
Temp.:
20 °C
pH:
4.3
Remarks on result:
other: Gel formed at about 500 g/L; as no discrete point can be identified, value estimated as above

Preliminary test:

The following aliquots of the test substance were added to 2 g of water and stirred slowly for 10 minutes:

Aliquot

Weighed sample, g

A

0.1

B

0.3

C

1.0

D

2.0

While being added to the water, solutions with increasing viscosity were being formed, resulting in a gel after the addition of 2 g of the test item.

With 2 g of test item being mixed into 2 g of water, a gel with a total weight of 4 g has been formed. This is equivalent to 50 % (w/w) of test item in solution/gel.

As the density of the water will significantly increase with addition of the test item, it can be concluded that the water solubility is about 500 g/L, resulting in a gel.

Due to the fact that the gel formation is a continuous process and no discrete point can be identified at which dissolution in water switches to gelling, the water solubility can be approximated to > 330 g/L.

Description of key information

> 330 g/L at 20 °C, pH =4.3

Key value for chemical safety assessment

Additional information

The water solubility of the substance was determined according to OECD Guideline 105 and EU Method A.6 (flask method). Gel formation at concentrations > 330 g/L was observed.