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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation, other
Type of information:
other: Expert Assessment
Adequacy of study:
weight of evidence
Study period:
March 2022
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Expert assessment based on structural alerts and QSAR models

Data source

Reference
Reference Type:
other: Expert Assessment
Title:
Unnamed
Year:
2022
Report date:
2022

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Predictions regarding the Eye Irritation potential of 6FDA were performed in the OECD QSAR Toolbox using the BfR rule-base profiling models which contains both physico-chemical exclusion rules and structure-based inclusion rules (structural alerts).
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphthalic anhydride
EC Number:
214-170-0
EC Name:
4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]diphthalic anhydride
Cas Number:
1107-00-2
Molecular formula:
C19H6F6O6
IUPAC Name:
4,4'-(hexafluoroisopropylidene)diphthalic anhydride

Results and discussion

In vitro

Results
Irritation parameter:
other: QSAR Prediction
Run / experiment:
N/A
Remarks on result:
no indication of irritation

Any other information on results incl. tables

No experimental data for the Eye Irritation of 6FDA was identified in the experimental database “Eye irritation ECETOC” in the OECD QSAR Toolbox. Therefore, for the purpose of this endpoint assessment report, predictions regarding the Eye Irritation potential of 6FDA were performed in the OECD QSAR Toolbox using the BfR rule-base profiling models which contains both physico-chemical exclusion rules and structure-based inclusion rules (structural alerts).


There was no indication of eye irritation/corrosion in both BfR rule-base profilers. In addition, when running the QSAR model called “BfR eye irritation/corrosion” using the OECD QSAR toolbox, a negative prediction was obtained for Eye Irritation/Corrosion.


Therefore, based on the results of the BfR rule-base profilers and QSAR model, 6FDA can be expected to not be irritating to the eyes.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
It was concluded that 6FDA would not be expected to induce irritation/corrosion to the eyes.
Executive summary:

The Eye Irritation potential of 6FDA was evaluated by identifying alerts using BfR rule-base profiling models (called “Eye Irritation/Corrosion exclusion rules by BfR” and “Eye Irritation/Corrosion inclusions rules by BfR”) and “BfR eye irritation/corrosion” QSAR model in the OECD QSAR Toolbox after a review of the literature did not identify usable experimental data.


As no alerts for Eye Irritation were returned from the BfR rule-base profilers and 6FDA Eye Irritation/Corrosion potential was estimated to be negative in “BfR eye irritation/corrosion” QSAR model, it was concluded that 6FDA would not be expected to induce irritation/corrosion to the eyes.