Registration Dossier
Registration Dossier
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EC number: 249-528-5 | CAS number: 29232-93-7
Endpoint summary
Administrative data
Description of key information
The substance exhibits short-term and long-term toxicity to various aquatic freshwater species from different trophic levels. Aquatic invertebrates appear to be most sensitive to exposure to the substance. Short-term studies on potential hormonal effects of the substance in the environment demonstrated no adverse effects on the hypothalamus-pituitary-gonadal (HPG) axis of spawning fish (Pimephales promelas) or the hypothalamus-pituitary-thyroid (HPT) axis of amphibian larvae (Xenopus laevis) over a period of 21 days.
Additional information
Table: Overview of key aquatic toxicity data available for the substance
Medium | Study | Species | Guideline/GLP | Endpoint | Effect level |
Freshwater | Short-term toxicity to fish | Oncorhynchus mykiss | OECD TG 203 / GLP | 96-h LC50 | 0.404 mg/L |
| Short-term toxicity to fish | Pimephales promelas | OECD TG 230 / GLP | 21-d NOEC | 0.215 mg/L |
| Long-term toxicity to fish | Oncorhynchus mykiss | OECD TG 204 / GLP | 28-d NOEC | <0.023 mg/L |
| Short-term toxicity to invertebrates | Daphnia magna | OECD TG 202 / GLP | 48-h EC50 | 0.314 µg/L |
| Long-term toxicity to invertebrates | Daphnia magna | OECD TG 211 / GLP | 28-d NOEC | 0.05 µg/L |
| Toxicity to algae | Raphidocelis subcapitata | OECD TG 201 / GLP | 72-h NOErC 72-h ErC50 | 0.30 mg/L 3.38 mg/L |
| Amphibian metamorphosis assay | Xenopus laevis | OECD TG 231 / GLP | 21-d NOEC | 0.035 mg/L |
Microorganisms | Toxicity to microorganisms | Pseudomonas putida | Bringmann and Kühn (1980) / GLP | 6-h NOEC | ≥4.5 mg/L |
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