Registration Dossier
Registration Dossier
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EC number: 208-831-2 | CAS number: 542-85-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Ethyl isothiocyanate
- EC Number:
- 208-831-2
- EC Name:
- Ethyl isothiocyanate
- Cas Number:
- 542-85-8
- Molecular formula:
- C3H5NS
- IUPAC Name:
- ethyl isothiocyanate
- Test material form:
- liquid
Constituent 1
In vitro test system
- Test system:
- human skin model
- Source species:
- human
- Vehicle:
- water
- Details on test system:
- The test item was applied as supplied , at the dose of 16µl to the epidermal surface of 3 living human skin model during 42h at room temperature.
- Control samples:
- yes, concurrent vehicle
- yes, concurrent positive control
- Amount/concentration applied:
- 16µl
- Duration of treatment / exposure:
- 42h
- Number of replicates:
- 3
Results and discussion
In vitro
Resultsopen allclose all
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- run 1
- Value:
- 1.9
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- run 2
- Value:
- 2.4
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- run 3
- Value:
- 2.8
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- mean
- Value:
- 2.4
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Other effects / acceptance of results:
- Negative control : mean viability = 100%
Positive control : mean viability = 1.8%
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- The skin irritation potential is evluated according OECD439 method. in the test conditions, the mean percent viability of the treated tissues was 2.4%. The test substance is considered as Irritating to skin.
- Executive summary:
The skin irritation potential is evluated according OECD439 method. in the test conditions, the mean percent viability of the treated tissues was 2.4%. The test substance is considered as Irritating to skin.
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