Registration Dossier
Registration Dossier
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EC number: 241-698-9 | CAS number: 17696-62-7
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Butylparaben [CAS No. 94-26-8], Review of Toxicological Literature
- Author:
- National Toxicology Program (NTP)
- Year:
- 2 005
- Bibliographic source:
- National Toxicology Program, NIEHS, National Institutes of Health, Contract No. N01-ES-35515
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The data presented is based on the results from a S. cerevisiae based Lac-Z reporter assay.
- GLP compliance:
- no
- Type of method:
- in vitro
- Endpoint addressed:
- other: estrogen receptor acitivity
Test material
- Reference substance name:
- Phenyl 4-hydroxybenzoate
- EC Number:
- 241-698-9
- EC Name:
- Phenyl 4-hydroxybenzoate
- Cas Number:
- 17696-62-7
- Molecular formula:
- C13H10O3
- IUPAC Name:
- phenyl 4-hydroxybenzoate
Constituent 1
Results and discussion
- Details on results:
- The 5-day EC50 was 2.28 x 10^-7 M. The relative gene activation was reported with 1.71 x 10^-2. The author concluded, that parabens were found to possess weak estrogen receptor activity in the Saccharomyces cerevisiae-based Lac-Z reporter assay.
Applicant's summary and conclusion
- Conclusions:
- The 5-day EC50 was 2.28 x 10^-7 M. The relative gene activation was reported with 1.71 x 10^-2. The author concluded, that parabens were found to possess weak estrogen receptor activity in the Saccharomyces cerevisiae-based Lac-Z reporter assay.
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