Registration Dossier
Registration Dossier
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EC number: 241-698-9 | CAS number: 17696-62-7
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Hazard for air
Hazard for terrestrial organisms
Hazard for predators
Additional information
Conclusion on classification
According to regulation (EC) No 1907/2006 toxicity tests with fish are not required for a tonnage of 1 to 10 tpa. Nevertheless, according to Article 12 of the mentioned regulation shall include all physicochemical, toxicological and ecotoxicological information that is relevant and available to the registrant. Three trophic levels (fish, daphnia, algae) are covered by the toxicity data set and can be used for hazard assessment. Fish species were observed to be the most sensitive species:
The available results from the fish studies reveal that fish is the most sensitive organism towards phenyl 4-benzoate and are therefore included in the present dossier and considered for classification according to Regulation (EC) No 1272/2008.
Two publications on short-term toxicity for fish are available indicating the following effect values:
The key study from Yamamoto et al. revealed a 96 h LC50 for Oryzias latipes. In the exposure experiment from Dobbins et al. (2009) a 48 h LC 50 of 3.3 mg/L was determined for Pimephales promelas, which is in the same range as the LC50 derived by Yamamoto et al. a 96 h LC50 for Oryzias latipas equalling 0.73 mg/L.
The lower value was set as key value for acute toxicity.
The key value for long-term toxicity to fish results from a VTG assay (14 -d exposure of male medaka). The effect concentrations from Yamamoto et al. (2011) were determined as follows:
LOEC: 20 µg/L a.i./L
NOEC: 100 µg a.i./L
A second long-term study (7 -day exposure of Pimephales promelas larvae, Dobbins et al. 2009) indicates similar values:
LOEC: 1.7 mg/L
NOEC: 0.85 mg/L
Based on the mentioned effect concentrations phenyl 4-hydroxybenzoate has to be classified as Aquatic Acute 1 (H400) and Aquatic Chronic 1 (H410).
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