Registration Dossier
Registration Dossier
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EC number: 234-988-1 | CAS number: 12049-50-2
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study planned
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Deviations:
- no
Reference
Description of key information
The water solubility of the registered substance was determined in accordance with the OECD Testing Guideline 105. The study concluded that Calcium Titanium Trioxide is poorly soluble in water (<0.3 mg/L).
As the substance is poorly soluble in water a long-term aquatic toxicity study should be considered instead of short-term studies. Therefore, short-term toxicity to aquatic invertebrates was waived in accordance with Annex VII of REACH.
During the OECD 105 it could not be excluded that nanoparticles of Calcium Titanium Trioxide will be available as a suspension in water. Therefore, due to its poorly soluble properties and to lack of certainty on suspended nanoparticles of Calcium Titanium Trioxide in water, a long term Daphnia Reproduction Test in accordance with the OECD Testing Guideline 211 is proposed (Annex IX of REACH).
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
