Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 234-988-1 | CAS number: 12049-50-2
Endpoint summary
Administrative data
Description of key information
The water solubility of the registered substance was determined in accordance with the OECD Testing Guideline 105. The study concluded that Calcium Titanium Trioxide is poorly soluble in water (<0.3 mg/L). During the OECD 105 it could not be excluded that nanoparticles of Calcium Titanium Trioxide will be available as a suspension in water.
As the substance is poorly soluble in water long-terms aquatic toxicity studies should be considered instead of short-term studies.
For the bulk form of the substance there are mitigating factors indicating that aquatic toxicity is unlikely to occur since the substance highly insoluble in water. Therefore, short-term toxicity to algae was waived in accordance with Annex VII of REACH.
For the nanoform of the substance insolubility in water alone is insufficient to waive aquatic toxicity to algae and cyanobacteria without proper and scientifically robust justification. As such, an expert assessment was conducted to discuss the aggregation or agglomeration behaviour of the substance in pure water, and in environmental water, using a combination of analytical data and scientific argument. As a result of this assessment and in accordance with Annex VII of REACH and ECHA (2016), it is concluded that there are no grounds for concern for the aquatic compartment given the insoluble nature of the substance, and its natural proclivity to form aggregates and/or agglomerates in solution, so that sedimentation is likely to occur. Moreover, the aggregates of the substance would be unable to cross the biological membranes of the aquatic species and are too large to pass through channels within the cells.
Due to its poorly soluble properties and to lack of certainty on suspended nanoparticles of Calcium Titanium Trioxide in water, a long term Daphnia Reproduction Test in accordance with the OECD Testing Guideline 211 is proposed (Annex IX of REACH).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
