Registration Dossier
Registration Dossier
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EC number: 500-740-9 | CAS number: 162492-07-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
There are no identified published data on the toxicokinetics of the test substance. However, as per REACH guidance document R7. C, information on absorption, distribution, metabolism and excretion may be deducted from the physico-chemical properties including:
- Water solubility
- Partition coefficient
- Vapour pressure
- Molecular weight
The test substance is a UVCB, with all constituents having a molecular weight >500. It is a solid with a water solubility of 12 mg/L at 20°C. Volatility was determined to be very low (2.1 E-18 Pa at 25°C) and the substance has a limited lipophilic character (log Kow of the major constituent: 1.6). Taking into account the log Kow and the water solubility, bioaccumulation of the test substance is considered to be unlikely.
Oral and gastrointestinal (GI) absorption: Given thewater solubility and partition coefficient of the substance, it is likely to be partially soluble in GI fluid. Based on the high molecular weight of the majority of the constituents, they can then be expected to be partially absorbed through the GI system. However, in the absence of actual data, a default value of 50% has been considered for oral absorption.
Inhalation absorption: Given the log Kow of the major constituent, systemic uptake of the test substance afterinhalationexposure could be expected, although this would occur only when aerosol or vapour is created under particular conditions (e.g. spraying, elevated temperature/pressure). In the absence of actual data, a default value of 100% has been considered for inhalation absorption.
Dermal absorption: Dermal absorption of the substance is expected to be limited. According to REACH guidance document R7.C, dermal absorption is maximal for substances with molecular weights below 500 and log Kow values ranging between 1 and 2. The test substance constituents have average molecular weights >500 and the log Kow of the major constituent is 1.6. This suggests that the substance may not penetrate easily through skin. Therefore, a conservative estimate of 50% has been considered for dermal absorption.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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