Registration Dossier
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EC number: 500-740-9 | CAS number: 162492-07-1
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- not specified
- Type of method:
- column elution method
- Specific details on test material used for the study:
- CAS No.: 162492-07-1; Batch No.: lab; Purity: unknown by the sponsor, treated as 100 % pure; Appearance: white to off-white solid
- Key result
- Water solubility:
- 12 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 5.37 g/L
- Incubation duration:
- 3 d
- Temp.:
- 20.4 °C
- pH:
- 7
- Remarks on result:
- other: based on the main component
- Remarks:
- 3 d (for column I and II); 6 d (for column III)
- Details on results:
- In a preliminary test, the water solubility of the test substance was determined to be 0.01 g/L, therefore the column elution method was chosen for the determination of the water solubility of the test substance.
Main study 1: During the test, it proved not possible to obtain a reliable value for water solubility.
Main study 2:
The eluates did not contain undissolved particles. In the chromatograms of samples from the blank column, small peaks were observed at the retention time of the test substance. Contribution to peak areas for samples from columns I-III was <1.5 % and therefore considered negligible.
The mean of the results obtained for Column I (10.8 mg/L), Column II (11.8 mg/L and Column III (13.5 mg/L) was calculated to be 12 mg/L. The maximum deviation between the results is 22 % using not rounded values. - Conclusions:
- Under the study conditions, the water solubility based on that of the major constituent is 12 mg/L at 20.4 ± 0.8°C.
- Executive summary:
A study was conducted to determine the solubility of the test substance according to OECD Guideline 105 and EU Method A.6, by the column elution method. The test substance is a UVCB. Under the study conditions, the water solubility based on that of the major constituent is 12 mg/L at 20.4 ± 0.8°C (Willems, 2003).
Reference
Description of key information
The solubility was determined according to OECD Guideline 105 and EU Method A.6, by the column elution method (Willems, 2003).
Key value for chemical safety assessment
- Water solubility:
- 12 mg/L
- at the temperature of:
- 20.4 °C
Additional information
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