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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Description of key information

- 677

Key value for chemical safety assessment

BCF (aquatic species):
677 dimensionless

Additional information

In a key study, the BCF of the constituents of Santicizer 148 in Pimephales promelas was determined according to methodology comparable to OECD guideline 305 in a 90 d partial life cycle test. Fish were exposed to nominal concentrations of 0.05, 0.09, 0.19, 0.38 and 0.75 mg/l for 90 days and observed during a depuration period for another 56 days. Concentrations in fish and water were determined using GC-analysis. The whole fish wet weight BCF for IDDP was found to 677 +/- 159.

Mortality during the exposure varied from 32 -40% in the solvent controls, but this was not significantly different from the mortality observed at each exposure concentration. In addition, fry rather than adult fish were tested. Although there are some notable restrictions to this study the exposure period was longer than required and conducted in a flow through system with analytical monitoring of the exposure concentrations. Visual inspection of the concentrations measured in fish tissue indicates that a steady state was reached well within the 90 days exposure and that there was rapid elimination during the deposition phase. The authors state that the DT50 for the depuration phase were less than 7 days.

An experimental BCF value is also cited within the EPIWEB QSAR BCFBAF for Santicizer 148. Although the original citation has not been reviewed here the experimental values used to derive the QSAR equations were reviewed for quality and this study was considered reliable. The results of this study are therefore considered reliable for use here, and have been used as a supporting study.

The BCF of Santicizer 148 in Cyprinus carpio was determined according to methodology comparable to OECD guideline 305. Fish were exposed to nominal concentrations of 10 µg/l for 56 days. Concentrations in fish and water were determined. The whole fish wet weight BCF for IDDP based on measured concentrations was found to 673 and the authors note that steady state was reached.