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EC number: 268-750-3
CAS number: 68134-38-3
Table 1: Summary of mean values without S9-mix from the pre-test
Table 3: Summary of mean values without S9-mix from the repeat tests
In a reverse gene mutation assay in bacteria, strains TA 1535, TA 100,
TA 1537, TA 98 of S. typhimurium were exposed to the test item (98.5%
purity) in methanol at concentrations of 8, 40, 200, 1000 and 5000
µg/plate (first/pre-test) and at concentrations of 25, 50, 100, 200,
400, 800 µg/plate (repeat test) in the presence and absence of mammalian
The test item was tested up to the limit concentration (5000 µg/plate).
Based on bacteriotoxic effects only the dose groups up to 1000 µg per
plate were used to a limited extent for assessment purposes. The
positive controls induced the appropriate responses in the corresponding
strains. In the studies with metabolic activation, a slight increase (up
to 1.6 fold) in the mutant count was observed. This slight increase was
not dose-dependent and did not occur in all experiments. In the studies
without metabolic activation no induction of mutant counts was observed.
Therefore, the test item is considered to be non-mutagenic with and
without S9 mix in the Salmonella/microsome test.
This study is classified as acceptable. The study satisfies the
requirement for Test Guideline OECD 471 for in vitro mutagenicity
(bacterial reverse gene mutation) data.
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