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Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification
Justification for type of information:
QSAR prediction

Data source

Reference
Reference Type:
other: Predicted data
Title:
Unnamed
Year:
2015

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: REACH guidance on QSARs R.6, May/July2008
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
Test item: 15-α-hydroxy-androstendioneCAS No.: 566-08-5Batch No.: D61053NPhysical state: yellowish white crystalline powderStorage: 15-30 °C

Results and discussion

Effect concentrationsopen allclose all
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
3.21 mg/L
Nominal / measured:
estimated
Remarks on result:
other: VegaNIC Database: EPA
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
4.5 mg/L
Nominal / measured:
estimated
Remarks on result:
other: T.E.S.T. (Hierarchical clustering method)

Applicant's summary and conclusion

Conclusions:
According to (Q)SAR modells: VegaNIC, T.E.S.T., the predicted values indicated that 15-α-hydroxy-androstendione is hazardous to the fishes. The result meets the requirement of Aquatic Acute Category 2.