Registration Dossier

Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification
Justification for type of information:
QSAR prediction

Data source

Reference
Reference Type:
other: Predicted data
Title:
Unnamed
Year:
2015

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: REACH guidance on QSARs R.6, May/July2008
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
Test item: 15-α-hydroxy-androstendioneCAS No.: 566-08-5Batch No.: D61053NPhysical state: yellowish white crystalline powderStorage: 15-30 °C

Results and discussion

In vivo (non-LLNA)

Results
Remarks on result:
positive indication of skin sensitisation
Remarks:
QSAR prediction

Any other information on results incl. tables

Software Method Endpoint Alert Predicted value
ChemProp Enoch et al Skin Sensitisation Structural Alerts were found. Active
Toxtree Skin sensitisation reactivity domains Skin Sensitisation Schiff Base Formation 1 alert
VegaNIC Skin Sensitisation model (CAESAR) Skin Sensitisation Structural Alerts Sensitizer

Applicant's summary and conclusion

Interpretation of results:
sensitising
Conclusions:
According to (Q)SAR modells: VegaNIC, Toxtree, ChemProp, the predicted values indicated that 15-α-hydroxy-androstendione is sensitiser. The result meets the requirement of Hazard Category 1B.