Registration Dossier

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification
Justification for type of information:
QSAR prediction

Data source

Reference
Reference Type:
other: Predicted data
Title:
Unnamed
Year:
2015

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: REACH guidance on QSARs R.6, May/July2008
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
Test item: 15-α-hydroxy-androstendioneCAS No.: 566-08-5Batch No.: D61053NPhysical state: yellowish white crystalline powderStorage: 15-30 °C

Results and discussion

Results of in vivo study
Remarks on result:
no indication of irritation
Remarks:
QSAR prediction

Any other information on results incl. tables

Software Method Alert Predicted value
ChemProp Eye irritation and corrosion No Structural Alerts were found. Likely save
Toxtree Eye irritation and corrosion No Structural Alerts were found. NOT eye irritation R36

Applicant's summary and conclusion

Interpretation of results:
not irritating
Conclusions:
According to (Q)SAR modells: ChemProp, Toxtree, the predicted values indicated that 15-α-hydroxy-androstendione is not irritating or corrosive to eye.