Registration Dossier
Registration Dossier
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EC number: 204-234-6 | CAS number: 118-10-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: There are no details on the method available.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- ALKALOIDS Toxicology
- Author:
- Wink, M.
- Year:
- 2 003
- Bibliographic source:
- http://de.scribd.com/doc/16524192/ALKALOIDS-Toxicology
Materials and methods
- Principles of method if other than guideline:
- There are no details on the method available.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cinchonine
- EC Number:
- 204-234-6
- EC Name:
- Cinchonine
- Cas Number:
- 118-10-5
- Molecular formula:
- C19H22N2O
- IUPAC Name:
- cinchonan-9-ol
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Cinchonine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 152 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no further information
Applicant's summary and conclusion
- Conclusions:
- The intraperitoneal LD50 of cinchonine, tested on rats is 152 mg/kg bw.
- Executive summary:
The acute toxicity of cinchonine was tested via an intraperitoneal injection. The experimental study published by Wink, 2003 showed that the LD50 of cinchonine, tested on rats is 152 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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